Results 41 to 50 of about 317,602 (265)
Language assessment of children with severe liver disease in a public service in Brazil
ClinicsOBJECTIVE: The aim of this research was to compare language development (expressive and receptive skills) in children awaiting liver transplantation with that of children who have already undergone the surgical procedure.
Erica Macêdo de-Paula +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Jornal de Pediatria (Versão em Português), 2015 Objective: To review the literature that addresses the relationship between prematurity, birth weight, and development of language in Brazilian children.
Amanda B. Zerbeto +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
DiagnosticsBackground/Objectives: Developmental Language Disorder (DLD) is a persistent neurodevelopmental condition with an estimated prevalence of 7% in preschoolers.
Diego Lourenço dos Santos Silva +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Infantile epileptic spasms syndrome caused by TBL1XR1 gene variation: three cases report
Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To summarize the clinical characteristics, genotypes and prognosis of infantile epileptic spasms syndrome (IESS) caused by TBL1XR1 gene variation.
LÜ Qiu +4 more
doaj +1 more source
Advances in Rehabilitation, 2018 The occurrence of problems linked to cognitive-linguistic and auditory processing may lead to serious phonological disorders such as an incorrect use of sounds by a child.
Dorota Religa +2 more
doaj +1 more source