Results 61 to 70 of about 317,602 (265)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Neuroimaging in pediatric language development and disorders: a scoping review protocol

Systematic Reviews
Background Infancy and early childhood represent critical periods for language development, as well as for the diagnosis and intervention of language disorders.
Ruochen Ning, Karla N. Washington
doaj   +1 more source

A Comparative Analysis of Language Skills and Parent–Child Interactions in Monolingual and Bilingual Children Born Preterm

Languages
Children born preterm are at an elevated risk of language delays compared to children born full-term. However, there is a dearth of research investigating language outcomes in premature children exposed to more than one language.
Kimberly Crespo, Emma Libersky, Julie Poehlmann, Margarita Kaushanskaya   +3 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

A duração da pausa silente difere entre palavras de classe aberta ou fechada?

Audiology: Communication Research
Objetivo Verificar se o tempo médio das pausas silentes difere para a classe das palavras (aberta ou fechada) e se há diferença entre esse tempo para crianças em desenvolvimento típico de linguagem e crianças com distúrbio específico de linguagem (DEL ...
Paula Renata Pedott, Letícia Bondezan Bacchin, Ana Manhani Cáceres-Assenço, Debora Maria Befi-Lopes   +3 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Language delay in the context of current scientific findings

Listy klinicke logopedie
The review study focuses on the topic of language delay (LD), which represents an early delay in language development. This early delay may be a symptom of certain neurodevelopmental disorders (autism spectrum disorders, developmental intellectual ...
Alžběta Zemánková
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Dual Language Development Disorders: A Handbook on Bilingualism & Second Language Learning

Domínios de Lingu@gem, 2013
O livro Dual language development and disorders: A Handbook on Bilingualism & Second Language Learning discorre sobre questões teóricas e práticas a respeito do ensino e da aprendizagem de uma segunda língua por crianças com ou sem algum transtorno de ...
Bernardo Kolling Limberger
doaj