Results 61 to 70 of about 838,388 (305)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Development of a language and communication screening test and identification of protective and risk factors associated with communication and language disorders [PDF]

, 2012
With the present research, we aimed to identify the principal risk and protective factors associated with the occurrence of a developmental language disorder and to develop a specific and sensible screening instrument, easy and rapid to use.
Martins, Paula Cristina, Peixoto, Vânia, Sousa, Inês   +2 more
core  

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Association between gestational age and birth weight on the language development of Brazilian children: a systematic review

Jornal de Pediatria (Versão em Português), 2015
Objective: To review the literature that addresses the relationship between prematurity, birth weight, and development of language in Brazilian children.
Amanda B. Zerbeto, Fernando M. Cortelo, Élio B.C. Filho   +2 more
doaj   +1 more source

Penyesuaian Diri Anak Luar Biasa (Studi Kasus Ade Irawan, Juara Pianis Tunanetra Indonesia) [PDF]

, 2014
Adjustment is the ability of individuals to associate with them self and environment. Children have experience growth and development in her both physically and mentally, covers an area ofmotor/biological, cognitive, and emotional development/affective ...
Aulia, F. (Fitri)
core  

The prompt hypothesis: clarification requests as corrective input for grammatical errors [PDF]

, 2005
The potential of clarification questions (CQs) to act as a form of corrective input for young children's grammatical errors was examined. Corrective responses were operationalized as those occasions when child speech shifted from erroneous to correct (E -
Dawson, Natasha, Houston-Price, Carmel, Saxton, Matthew   +2 more
core   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Semantic and inferencing abilities in children with communication disorders [PDF]

, 2005
Background: Semantic and inferencing abilities have not been fully examined in children with communication difficulties. Aims: To investigate the inferential and semantic abilities of children with communication difficulties using newly designed tasks.
Cesarini M, Danese S, Fiorino G, Malesci A, Sorrentino D   +4 more
core   +3 more sources

Development of Print Awareness in Language-Disordered Preschoolers

Journal of Speech, Language, and Hearing Research, 1985
This study examined print awareness and related oral language abilities in language-disordered and normally developing preschoolers. Twenty subjects, ages 3:1 to 6:5 (years:months), were shown high frequency environmental print in four conditions varying in the amount of non-print information present in the print setting.
Gillam, Ronald B., Johnston, J.
openaire   +3 more sources