Results 131 to 140 of about 195,033 (294)
2008 15th Working Conference on Reverse Engineering, 2008 By abstraction and factoring out domain specific knowledge, model driven engineering addresses the problem of increasing software complexity. Both models and meta models are generally subject to evolution, yet evolution of a meta model can cause conforming models to no longer conform and thereby no longer be usable.
openaire +3 more sources
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Compositionality, Complexity, and Evolution [Elektronisk resurs]
, 2013 Is there a reason to believe that the evolution of language leads to compositional semantics? A proposal from Henry Brighton is presented and criticized.
Pagin, Peter,
core
The role of practice and literacy in the evolution of linguistic structure
, 2010 Recent iterated language learning studies have shown that artificial languages evolve over the generations towards regularity. This trend has been explained as a reflection of the learners’ biases.
Brown, J. Erin +7 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Non-Arbitrariness across modalities : Bootstrapping the emergence and development of questions [PDF]
, 2022 Heim, Johannes, Cuskley, Christine
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
, 2018 1. IntroductionA major component in the evolution of language is the evolution of the human language capacity, whatever biological endowments humans have that make us language-ready.
Johansson, Sverker,
core
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source