Results 51 to 60 of about 1,227,478 (315)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

HOW PARENTS FOSTER BILINGUALISM IN THE FAMILY: A CASE STUDY OF AN INDONESIAN STUDENT FAMILY IN PERTH, WESTERN AUSTRALIA

International Journal of Education, 2017
This study investigated how Indonesian children in Australia as a foreign country temporarily switch their Indonesian language with English, what parents’ attitudes toward the children’s language is, and how Indonesian parents encourage the use of Bahasa
Lilis Ummi Fa’iezah
doaj   +1 more source

INFLUENTIAL FACTORS IN THE MAINTENANCE OF TAMIL LANGUAGE AMONG INDIAN SOCIETIES IN MEDAN, NORTH SUMATERA [PDF]

, 2015
The research is aimed at finding out the influential factors in the maintenance of Tamil language among Indian societies in Medan North Sumatera, It is used descriptive research by using qualitative and quantitative approach.
Djamereng , Jumharia
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Exploring Family Language Policy: Parental Perspectives in Homshetsma-Speaking Families

Dilbilim Araştırmaları Dergisi
The preservation of heritage languages often relies on family language policies (FLP), shaped by parental attitudes and practices (Fishman, 1991). This study investigates FLP in Homshetsma-speaking families, focusing on the endangered status of the ...
Gülay AKIN
doaj   +1 more source

Afrikaans as an index of identity among Western Cape Coloured communities

Stellenbosch Papers in Linguistics, 2011
In South Africa, reports on language shift have focused on instances of language shift from indigenous African languages to English. There is, however, also research that suggests that language shift is taking place from Afrikaans to English in the ...
Thutloa, Alfred Mautsane, Huddlestone, Kate   +1 more
doaj   +1 more source

A Systematic Review of Recall Regimen and Maintenance Regimen of Patients with Dental Restorations. Part 2: Implant-Borne Restorations [PDF]

, 2015
Purpose To evaluate the current scientific evidence on patient recall and maintenance of implant-supported restorations, to standardize patient care regimens and improve maintenance of oral health. An additional purpose was to examine areas of deficiency
Bidra, Avinash S., Chandler, Nancy Deal, Curtis, Donald A., Daubert, Diane M., Garcia, Lily T., Gauthier, Marissa F., Kosinski, Timothy F., Nenn, Conrad A., Olsen, John A., Platt, Jeffrey A., Wingrove, Susan S.   +10 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

IAD annual report [PDF]

, 2006
The Institute for Aboriginal Development Incorporated (IAD) was established by the Uniting Church in 1969 to assist community development for Aboriginal people and provide cross-cultural education between Aboriginal and non-Aboriginal society.
Institute for Aboriginal Development
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source