Results 61 to 70 of about 4,878,713 (296)
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Home and school literacy practices of children attending Malayalam classes in Singapore
Journal of Modern Languages, 2020 The Malayalee community, a minority language group in Singapore, lacks institutional support for learning their mother tongue in schools. In school, most Malayalee children opt to study Tamil or Hindi, a Non-Tamil Indian Language (NTIL) in place of ...
Suvita Thanagopalasamy +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Reason Maintenance - Conceptual Framework [PDF]
, 2009 This paper describes the conceptual framework for reason maintenance developed as part of ...
Bry, François, Kotowski, Jakub
core +1 more source
Language Shift and Language Maintenance in Indonesia [PDF]
, 2014 Indonesia is a large nation in terms of both geography and population, and a very large number of languages are spoken within its territory. Historically, multilingualism was and is the norm in many parts of the archipelago, and common even in areas where one language dominates.
openaire +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Spanish as Immigrant Minority Language in Brussels: A Pilot Study on Maintenance and Vitality
LanguagesDespite its demographic relevance, Spanish as an Immigrant Minority Language (IML) remains understudied in Europe. In Brussels, approximately 46,500 residents have Hispanic heritage, but their linguistic practices have largely remained unexplored in ...
Samantha Pérez Rodríguez +2 more
doaj +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source