Results 61 to 70 of about 86,036 (308)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Strategies of University Training Bachelors of Translation in the Ukrainian Danubian Region

Journal of Danubian Studies and Research, 2021
The purpose of the article is to identify the practical and theoretical components in the preparation of training programs and courses on the theory and practice of translation, the practice of foreign languages, linguo- cultural studies and ...
Tetiana Soroka
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Sociolinguistic projects of the "Language Unit of the Year" type: categorization and dynamics of development

Гуманитарные и юридические исследования
Introduction. The paper provides a complex system analysis of sociolinguistic projects of the "Language Unit of the Year" type in various linguistic cultures.
T. A. Dolgaya
doaj   +1 more source

K. I. CHUKOVSKY-TRANSLATOR: A PORTRAIT AND A SELF-PORTRAIT IN THE METATEXT

Гуманитарные и юридические исследования, 2021
Among numerous creative achievements of the outstanding master of the Russian word K.I. Chukovsky the important place is taken by his work «Translation art» («High art»). In the field of the translation he is known as a translator whose main principle of
A. A. Agajanjan
doaj  

Concept «soul» in the language picture of the pupils' world

Язык и текст, 2017
The article deals with the concept of «soul» from the methodological point of view: the effectiveness of its analysis at the Russian language lessons for the formation of linguistic, communicative and cultural competences in fifth class while ...
M.P. Mulina
doaj   +1 more source

Semantic Field as a Fragment of National World Language Picture

, 2017
The article considers the semantic field gentleness/nobleness as a fragment of the English national world picture. The semantic fields are the structures that constitute the general semantic sphere of any language.
G T Bezkorovaynaya
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

THE NATIONAL LANGUAGE PICTURE OF THE WORLD: THE TRIAD LANGUAGE – CULTURE – HUMAN

Naukovì zapiski Nacìonalʹnogo unìversitetu «Ostrozʹka akademìâ». Serìâ «Fìlologìâ», 2021
In this article the anthropocentric approach to the study of the national language picture of the world through the prism of linguistic and cultural interaction is offered; the role of non-equivalent vocabulary in the language and conceptual picture of the world is determined due to the theoretical and methodological principles of the linguocultural ...
openaire   +2 more sources