Results 71 to 80 of about 86,036 (308)

THE LINGUISTIC PICTURE OF THE WORLD AND ITS THEORETICAL JUSTIFICATION

open access: yes, 2023
Russian language picture of the world through the prism of phraseological units based on the material of modern Russian prose, which is based on the study of the structure and semantics of the expression of phraseological units at various levels of the ...
Atadjanova Gulbaxar Yusupovna   +1 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Language picture of the world: problem of components` organization

open access: yes, 2013
У статті розглядаються сфери дослідження мовної картини світу (МКС), установлюються її характерні дефініції та ключові проблеми, у тому числі і зв’язок з концептуальною картиною світу (ККС).
Огуй, О.Д.
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

ZOOPHRASEOLOGISMS AND ZOOLEXEMES AS EXPLICATORS OF THE LINGUISTIC WORLD PICTURE OF THE RUSSIAN AND THE CHINESE LANGUAGES

open access: yesВестник Кемеровского государственного университета, 2016
The paper is devoted to the study of the Russian and the Chinese phraseology, which includes lexical components with names of animals. The purpose of this paper is to reveal the peculiarities of perception and functioning of zoophraseologisms and ...
Olga A. Bulgakova, Olga A. Krasnoborova
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

"Emotion" in the Russian and English language pictures of the world

open access: yesLitera, 2023
The article describes the functioning of the concepts "emotion" in Russian and English. Emotion as a phenomenon of reality has a multifaceted logical nature, is culturally, lexically and axiologically conditioned. The structure of concepts that can be evaluated as equivalents formalizes the categorization and conceptualization of reality, shows a ...
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

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