Results 41 to 50 of about 242,129 (302)
A reference guide to the syntax of North American Norwegian
North American Norwegian (NAmNo) is a diasporic heritage variety of Norwegian spoken primarily in the Upper Midwest of the United States. NAmNo has been in use since the mid-19th century, but it is now moribund.
Lundquist, Björn +13 more
core +7 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Language policy and nation-building in post-apartheid South Africa.
, 2007 PhDWhile not essential, the link between language and national identity is nevertheless often a highly important and salient one, a fact illustrated by the centrality of linguistic concerns in many nationalist discourses throughout the world.
Orman, J, Orman, Jon., Orman, Jon
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Reconsidering language shift within Singapore’s Chinese community: A Bourdieusian analysis
, 2017 The official narrative told by national census data in Singapore is that of massive language shift within one generation from a myriad of Chinese dialects towards Mandarin and English as dominant home languages.
Bokhorst-Heng, W. D. (Wendy Diana) +1 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
ATTITUDES OF INDIGENOUS ACEHNESE PEOPLE TOWARDS THEIR VERNACULAR MAINTENANCE IN LANGSA.
JL3T (Journal of Linguistics, Literature and Language Teaching), 2017 This research is a study on native people’s attitudes towards Acehnese language in Langsa Aceh. The research design used a qualitative research method that examines the attitudes of native speakers of the language of Aceh in Langsa in prewserving the ...
Fakhrurrazi Fakhrurrazi
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source