Results 41 to 50 of about 4,815,658 (272)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Weak function word shift [PDF]
, 2004 The fact that object shift only affects weak pronouns in mainland Scandinavian is seen as an instance of a more general observation that can be made in all Germanic languages: weak function words tend to avoid the edges of larger prosodic domains.
Vogel, Ralf
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Straw that Broke the Language's Back: Language Shift in the Upper Necaxa Valley of Mexico [PDF]
, 2009 This article examines the factors that have led to a shift to Spanish in the Upper Necaxa Totonac communities of east-central Mexico. Despite the fact that Spanish and Totonac have been in contact since before the eighteenth century, the shift to the ...
Lam, Y., Dorian, N.C.
core +1 more source
GlottodidacticaThis paper examines the trends of language shift and its impact on language pedagogy, especially in the increasingly multilingual case context of the Kathmandu Valley.
Bhim Lal Gautam, Prem Prasad Poudel
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The Dynamics of Language Shift among Lawa-Speaking Families in Northern Thailand
Journal of the Southeast Asian Linguistics Society, 2022 This paper examines Lawa language shift, vitality, and endangerment on the family level in Northern Thailand using a six-question set adapted from the five key questions of the Expanded Graded Intergenerational Disruption Scale (EGIDS).
Panyawuthakrai, Rakkhun +1 more
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
ATTITUDES OF INDIGENOUS ACEHNESE PEOPLE TOWARDS THEIR VERNACULAR MAINTENANCE IN LANGSA.
JL3T (Journal of Linguistics, Literature and Language Teaching), 2017 This research is a study on native people’s attitudes towards Acehnese language in Langsa Aceh. The research design used a qualitative research method that examines the attitudes of native speakers of the language of Aceh in Langsa in prewserving the ...
Fakhrurrazi Fakhrurrazi
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source