Results 91 to 100 of about 678,533 (300)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Courage, Success, Faith…? But Now What Is Courage in Politics?

open access: yesActa Universitatis Sapientiae: European and Regional Studies, 2021
Barnucz Nóra
doaj   +1 more source

Шляхи реалізації компетентнісного підходу при навчанні студентів іноземної мови за професійним спрямуванням [PDF]

open access: yes, 2011
UK: В статті концептуалізовано інтерпретацію компетентнісного підходу при реалізації іншомовної підготовки студентів в системі вищої професійної освіти в умовах її модернізації.
Мунтян, Світлана Геннадіївна   +2 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Professional education and languages: teaching languages for specific purposes

open access: yes, 2021
- Este artigo tem o objetivo de investigar a relação entre a abordagem instrumental no ensino de inglês nos cursos técnicos de nível médio nas escolas técnicas estaduais do estado de São Paulo e as escolhas mais adequadas ao ensino por competências. Concentra-se no conceito de análise de necessidades por ser o diferencial dessa abordagem.
Langhi, Celi   +3 more
openaire   +1 more source

Manuscriptorium Digital Library and ENRICH Project: Means for Dealing with Digital Codicology and Palaeography [PDF]

open access: yes, 2009
Codicology and palaeography in the digital age can be developed both through adapting existing methods and using information and communication technologies.
Knoll, Adolf, Uhlíř, Zdeněk
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Hydrological Models as Web Services: An Implementation using OGC Standards

open access: yes, 2012
Presentation for the HIC 2012 - 10th International Conference on Hydroinformatics. "Understanding Changing Climate and Environment and Finding Solutions" Hamburg, Germany July 14-18, 2012  
Buytaert, W, Reusser, D, Vitolo, C
core   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

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