Results 31 to 40 of about 18,195 (260)
The Pharmacogenetics of Cytochrome P450 2C19 Enzymes - Effects on Clopidogrel and Proton Pump Inhibitors [PDF]
, 2014 BACKGROUND: Cytochrome P450 (CYP) enzymes play important roles in human, including drug metabolism. CYP2 is the largest family of human CYP, with its sequence comprising almost one third of all CYP sequences, and responsible for the metabolism of ...
Muliaty, D. (Dewi) +1 more
core +4 more sources
EBioMedicine, 2015 The transcription factor, runt-related transcription factor 2 (Runx2), plays a pivotal role in the differentiation of the mesenchymal stem cells to the osteochondroblast lineages.
Kenichi Mishima +7 more
doaj +1 more source
Acta Dermato-Venereologica, 2021 is missing (Short communication)
Ryoko Kimura +4 more
doaj +1 more source
Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers [PDF]
, 2019 Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment ...
Gieling, Roben, Williams, Kaye J.
core +2 more sources
Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. [PDF]
, 2017 The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca2+ signals that regulate a diverse array of biological processes.
Rahman, Saifur, Rahman, Taufiq
core +2 more sources
PLoS Medicine, 2017 BackgroundRecent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity.
Tom A Yates +6 more
doaj +1 more source
Effectiveness of ranitidine bismuth citrate and proton pump inhibitor based triple therapies of Helicobacter pylori in Turkey [PDF]
Libyan Journal of Medicine, 2011 Background : Helicobacter pylori infection is the main cause of gastritis, gastroduodenal ulcer disease, MALT lymphoma, and adenocarcinoma of the stomach. The reported prevalence of H. pylori in the adult population in Turkey is 67.6%–81.3%.
Mustafa Iscan, Feriha Oz, Huseyin Alkim
doaj +1 more source
Lymphocytic Colitis Associated with Lansoprazole Treatment
Current Therapeutic Research, 2007 There have been several reported cases of lansoprazole-associated collagenous colitis (CC) reported in the literature but only 1 reported case of lansoprazole-associated lymphocytic colitis (LC) in the literature. Both CC and LC are considered inflammatory bowel diseases, but they are distinctly classified based on the condition of the colon, which is ...
Alagozlu, Hakan +3 more
openaire +4 more sources
E-Journal of Chemistry, 2010 An unknown impurity in lansoprazole (2-[[[3-methyl-4-(2, 2, 2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl] benzimidazole) was detected by HPLC and was identified as des-(trifluoroethoxy) lansoprazole, an principal synthetic route indicative impurity of ...
K. S. V Srinivas +3 more
doaj +1 more source
The proton-pump inhibitor lansoprazole enhances amyloid beta production.
PLoS ONE, 2013 A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases.
Nahuai Badiola +8 more
doaj +1 more source