Results 21 to 30 of about 16,188 (197)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Pharmacologic Properties of Proton Pump Inhibitors [PDF]

, 2003
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90231/1/phco.23.13.74S.31929 ...
Welage, Lynda S.
core   +1 more source

Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study [PDF]

, 2017
journal ...
Ashida, Kiyoshi, Funao, Nobuo, Kawai, Takashi, Matsumoto, Yasushi, MIZOKAMI, Yuji, Nishimura, Akira, Oda, Kazunori, Sugano, Kentaro   +7 more
core   +2 more sources

Pharmacodynamics and Pharmacokinetics of a New Type of Compound Lansoprazole Capsule in Gastric Ulcer Rats and Beagle Dogs: Importance of Adjusting Oxidative Stress and Inflammation

Pharmaceutics, 2019
: The aim of this study was to investigate the pharmacodynamics and pharmacokinetics of a new type of compound lansoprazole capsule in gastric ulcer rats and beagle dogs in order to confirm whether it is more effective in treating gastric ulcers and its ...
Binbin Wei, Yan Wang, Huizhe Wu, Mingyan Liu, Weifan Yao, Minjie Wei   +5 more
doaj   +1 more source

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization [PDF]

, 2007
UNLABELLED: PHOSPHO1 is a phosphatase highly expressed in bone. We studied its functional involvement in mineralization through the use of novel small molecule inhibitors.
Ali, Anderson, Anderson, Anderson, Anderson, Anderson, Anderson, Anderson, Baykov, Bernard, Cecil, Colin Farquharson, Dympna Harmey, Fallon, Fawzi, Garimella, Gomez, Harmey, Harmey, Hatch, Hessle, Ho, Houston, Houston, Houston, Hoylaerts, Hsu, Hunter, Johnson, Johnson, José Luis Millán, Kanehisa, Kvam, Lanzafame, Majeska, McLean, Meyer, Miao, Montessuit, Montessuit, Morris, Moss, Murshed, Nagaya, Narisawa, Nurnberg, Pelech, Rezende, Roberts, Roberts, Robison, Schinke, Scott Roberts, Sodek, Sonoko Narisawa, Stewart, Stewart, Suzuki, Terkeltaub, Valhmu, Wang, Wang, Waymire, Whyte, Wu, Wu, Wu, Zelinski   +67 more
core   +1 more source

Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System

Biomedicines, 2023
Lansoprazole (LZP) is used to treat acid-related gastrointestinal disorders; however, its low aqueous solubility limits its oral absorption. Black seed oil (BSO) has gastroprotective effects, making it a promising addition to gastric treatment regimens ...
Abdelrahman Y. Sherif, Ahmad Abdul-Wahhab Shahba   +1 more
doaj   +1 more source

Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase [PDF]

, 2014
Fatty acid synthase (FASN), the enzyme responsible for de novo synthesis of free fatty acids, is up-regulated in many cancers. FASN is essential for cancer cell survival and contributes to drug resistance and poor prognosis.
Fako, Valerie E., Liu, Jing-Yuan, Pflug, Beth, Wu, Xi, Zhang, Jian-Ting   +4 more
core   +5 more sources

Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis [PDF]

, 2005
Aim: To systematically evaluate the efficacy of H2-receptor antagonists (H2RAs) and proton pump inhibitors in healing erosive esophagitis (EE). Methods: A meta-analysis was performed.
Huang, JQ, Lam, SK, Wang, WH, Wong, BCY, Wong, WM, Xia, HHX, Zheng, GF   +6 more
core   +1 more source

Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort.

PLoS Medicine, 2017
BackgroundRecent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity.
Tom A Yates, Laurie A Tomlinson, Krishnan Bhaskaran, Sinead Langan, Sara Thomas, Liam Smeeth, Ian J Douglas   +6 more
doaj   +1 more source

Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signaling pathways

Molecular Medicine, 2022
Background Many clinical studies have shown a correlation between proton pump inhibitors (PPIs) and osteoporosis or fractures. The purpose of this study was to establish a murine model of chronic oral PPI administration to verify whether PPIs caused bone
Ziping Cheng, Yangjie Liu, Mengyuan Ma, Shiyu Sun, Zengqing Ma, Yu Wang, Liyuan Yu, Xuping Qian, Luning Sun, Xuehui Zhang, Yun Liu, Yongqing Wang   +11 more
doaj   +1 more source