Results 51 to 60 of about 24,009 (265)

Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis

EBioMedicine, 2015
The transcription factor, runt-related transcription factor 2 (Runx2), plays a pivotal role in the differentiation of the mesenchymal stem cells to the osteochondroblast lineages.
Kenichi Mishima, Hiroshi Kitoh, Bisei Ohkawara, Tatsuya Okuno, Mikako Ito, Akio Masuda, Naoki Ishiguro, Kinji Ohno   +7 more
doaj   +1 more source

Treatment of Digital Ulcers and Reflux Oesophagitis in a Patient with Systemic Sclerosis: Increased Risk of Hepatotoxicity due to a Potential Drug-drug Interaction Between Bosentan and Vonoprazan

Acta Dermato-Venereologica, 2021
is missing (Short communication)
Ryoko Kimura, Kazunari Sugita, Takaaki Sugihara, Hajime Isomoto, Osamu Yamamoto   +4 more
doaj   +1 more source

Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers [PDF]

, 2019
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment ...
Gieling, Roben, Williams, Kaye J.
core   +2 more sources

Phase III, randomised, double-blind, multicentre study to evaluate the efficacy and safety of vonoprazan compared with lansoprazole in Asian patients with erosive oesophagitis

Gut, 2019
Objective To establish the non-inferior efficacy of vonoprazan versus lansoprazole in the treatment of Asian patients with erosive oesophagitis (EO). Design In this phase III, double-blind, multicentre study, patients with endoscopically confirmed EO ...
Yinglian Xiao, Shutian Zhang, N. Dai, G. Fei, K. Goh, H. Chun, B. Sheu, C. Chong, Nobuo Funao, Wen Zhou, Minhu Chen   +10 more
semanticscholar   +1 more source

Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort.

PLoS Medicine, 2017
BackgroundRecent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity.
Tom A Yates, Laurie A Tomlinson, Krishnan Bhaskaran, Sinead Langan, Sara Thomas, Liam Smeeth, Ian J Douglas   +6 more
doaj   +1 more source

Comparative efficiency and safety of potassium competitive acid blockers versus Lansoprazole in peptic ulcer: a systematic review and meta-analysis

Frontiers in Pharmacology
Background: Lansoprazole, a proton-pump inhibitor (PPI), is the primary therapy for peptic ulcers (PU). Potassium competitive acid blockers (P-CAB) offer an alternative for acid suppression.
Yongqi Dong, Hongyan Xu, Zhihuan Zhang, Zhihang Zhou, Qiang Zhang   +4 more
semanticscholar   +1 more source

Effectiveness of ranitidine bismuth citrate and proton pump inhibitor based triple therapies of Helicobacter pylori in Turkey [PDF]

Libyan Journal of Medicine, 2011
Background : Helicobacter pylori infection is the main cause of gastritis, gastroduodenal ulcer disease, MALT lymphoma, and adenocarcinoma of the stomach. The reported prevalence of H. pylori in the adult population in Turkey is 67.6%–81.3%.
Mustafa Iscan, Feriha Oz, Huseyin Alkim
doaj   +1 more source

Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. [PDF]

, 2017
The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca2+ signals that regulate a diverse array of biological processes.
Rahman, Saifur, Rahman, Taufiq
core   +2 more sources

Comparison of Tegoprazan and Lansoprazole in Patients With Erosive Esophagitis up to 4 Weeks: A Multi‐Center, Randomized, Double‐Blind, Active‐Comparator Phase 4 Trial

Neurogastroenterology and Motility
The aims of this study were to confirm the non‐inferiority of tegoprazan to lansoprazole up to week 4 in patients with erosive esophagitis (EE) and to evaluate its effectiveness in rapid mucosal healing and symptom relief at week 2.
Cheol Min Shin, Suck-Chei Choi, Jin-Woong Cho, Seung Young Kim, O. Lee, Do Hoon Kim, Y. Cho, Ju Yup Lee, Sang Kil Lee, Jeong Eun Shin, Gwang Ha Kim, Seon-Young Park, Su Jin Hong, Hye-Kyung Jung, Sang Jin Lee, Young Hoon Youn, Seong Woo Jeon, In-Kyung Sung, Moo‐In Park, Oh Young Lee   +19 more
semanticscholar   +1 more source

Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurity in Lansoprazole

E-Journal of Chemistry, 2010
An unknown impurity in lansoprazole (2-[[[3-methyl-4-(2, 2, 2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl] benzimidazole) was detected by HPLC and was identified as des-(trifluoroethoxy) lansoprazole, an principal synthetic route indicative impurity of ...
K. S. V Srinivas, K. Mukkanti, R. Buchi Reddy, P. Srinivasulu   +3 more
doaj   +1 more source