Results 31 to 40 of about 126,983 (266)

Heterotropic pregnancy: Rare occurrence of a 12- week ruptured right isthmo-cornual ectopic along with a viable intrauterine pregnancy

Journal of Human Reproductive Sciences, 2012
Heterotropic pregnancy, although a rare condition, is associated with a greater frequency in assisted reproduction. It occurs in approximately 1 in 100 pregnancies conceived by in vitro fertilization (IVF) particularly when multiple embryos are ...
Priya Selvaraj, Kamala Selvaraj
doaj   +1 more source

Disseminated Peritoneal Hydatidosis: A Case Report

Journal of Nepal Medical Association
Hydatid disease or echinococcosis is caused by a tapeworm of the genus Echinococcus. Several cases of hepatic hydatid cysts are reported worldwide, but disseminated peritoneal hydatidosis with spontaneous rupture of cysts leading to ascites is a rare ...
Shashi Yadav, Prajwal Neupane, Kunal Pathak, Amit Bhattarai, Ujjwal Kumar Jha   +4 more
doaj   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Case Report : Spontaneous Caecal Rupture – A Disaster [PDF]

International Journal of Anatomy Radiology and Surgery, 2016
We present a case of a spontaneous caecal rupture in a 70 years old man with history of undergoing Trans Urethral Resection of Prostate (TURP) prior to the above presentation.
Aditya Arvind Manekar, Nishigandh Dnyaneshwar Patil, Tushar B Patil   +2 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

PREDICTORS OF THE DEVELOPMENT OF POSTOPERATIVE VENTRAL HERNIAS AND THEIR PREVENTION IN URGENT SURGERY

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2020
The problem of predicting and preventing postoperative ventral hernias is highly relevant. We examined 450 patients to identify predictors of hernia formation and determine its risk.
A. V. Fedoseev, A. S. Inyutin, S. N. Lebedev, V. S. Shklyar   +3 more
doaj  

Rare Case of Ileal Perforation [PDF]

Journal of Clinical and Diagnostic Research, 2013
Ileitis, or inflammation of the ileum, is often caused by Crohn’s disease. However, ileitis may be caused by a wide variety of other diseases.
Vinod Kumar B, John Joseph S Martis, Sheldon G Mathias, Priyatham Kamath, Vivek Shetty   +4 more
doaj   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

ORGAN-PRESERVING INTERVENTIONS IN SURGICAL CORRECTION OF SPLEEN CYSTS IN CHILDREN

Acta Medica Leopoliensia, 2023
The surgical approach to splenic cyst treatment in children is rather controversial. There are different organ-preserving surgeries available to treat children with the spleen affected by cystic lesions.
Andriy Kuzyk
doaj   +1 more source