Results 11 to 20 of about 21,874 (160)

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Synergistic Antitumor Activity and Mechanism of Lapatinib and Paclitaxel in Esophageal Cancer Cells

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the anti-tumor activity and mechanism of lapatinib, paclitaxel and their combination on esophageal cancer cells EC109. Methods MTT assay was used to detect the effects of lapatinib (1, 2, 4, 8 μmol/L), paclitaxel (5, 10, 20, 40 ...
CHEN Tao, LI Xiongwei, SUN Xiaodong
doaj   +1 more source

Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo

Biological Procedures Online, 2023
Background Resistance to HER2-targeted therapies, including the monoclonal antibody trastuzumab and tyrosine kinase inhibitor lapatinib, frequently occurs and currently represents a significant clinical challenge in the management of HER2-positive breast
Hao Liu, Sanbao Ruan, Margaret E. Larsen, Congcong Tan, Bolin Liu, Hui Lyu   +5 more
doaj   +1 more source

Lapatinib Suppresses HER2-Overexpressed Cholangiocarcinoma and Overcomes ABCB1– Mediated Gemcitabine Chemoresistance

Frontiers in Oncology, 2022
BackgroundRecent breakthroughs in cholangiocarcinoma (CCA) genomics have led to the discovery of many unique identifying mutations, of which HER2 has been found to be overexpressed specifically in cases of extrahepatic CCA.
Zhiqing Bai, Zhiying Guo, Jiaxing Liu, Yu-Ann Chen, Qian Lu, Ping Zhang, Lili Hong, Yunfang Wang, Jiahong Dong, Jiahong Dong   +9 more
doaj   +1 more source

Novel Cytochrome P450-3A4 Enzymatic Nanobiosensor for Lapatinib (a Breast Cancer Drug) Developed on a Poly(anilino-co-4-aminobenzoic Acid-Green-Synthesised Indium Nanoparticle) Platform

Biosensors, 2023
Breast cancer (BC) is one of the most common types of cancer disease worldwide and it accounts for thousands of deaths annually. Lapatinib is among the preferred drugs for the treatment of breast cancer. Possible drug toxicity effects of lapatinib can be
Jaymi Leigh January, Ziyanda Zamaswazi Tshobeni, Nokwanda Precious Pearl Ngema, Abongile Nwabisa Jijana, Emmanuel Iheanyichukwu Iwuoha, Takalani Mulaudzi, Samantha Fiona Douman, Rachel Fanelwa Ajayi   +7 more
doaj   +1 more source

RETRACTED ARTICLE: Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models

Breast Cancer Research, 2014
Introduction Src tyrosine kinase overactivation has been correlated with a poor response to human epidermal growth factor receptor 2 (HER2) inhibitors in breast cancer.
Luigi Formisano, Lucia Nappi, Roberta Rosa, Roberta Marciano, Claudia D’Amato, Valentina D’Amato, Vincenzo Damiano, Lucia Raimondo, Francesca Iommelli, Antonella Scorziello, Giancarlo Troncone, Bianca Maria Veneziani, Sarah J Parsons, Sabino De Placido, Roberto Bianco   +14 more
doaj   +1 more source

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

BMC Cancer, 2019
Background Chemoresistance is an obstacle to the successful treatment of nasopharyngeal carcinoma (NPC). Lapatinib is a targeted tyrosine kinase inhibitor therapeutic drug also used to treat NPC, but high doses are often required to achieve a result.
Sathid Aimjongjun, Zimam Mahmud, Yannasittha Jiramongkol, Glowi Alasiri, Shang Yao, Ernesto Yagüe, Tavan Janvilisri, Eric W.-F. Lam   +7 more
doaj   +1 more source

Lapatinib Plus Local Radiation Therapy for Brain Metastases From HER-2 Positive Breast Cancer Patients and Role of Trastuzumab: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2020
BackgroundIntracranial activity of lapatinib has been demonstrated in several studies in patients with human epidermal growth factor receptor-2 positive breast cancers (HER-2+ BC).
Muhammad Khan, Muhammad Khan, Zhihong Zhao, Sumbal Arooj, Sumbal Arooj, Tao Zheng, Guixiang Liao   +6 more
doaj   +1 more source

Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds. [PDF]

PLoS ONE, 2013
Human African trypanosomiasis is caused by the eukaryotic microbe Trypanosoma brucei. To discover new drugs against the disease, one may use drugs in the clinic for other indications whose chemical scaffolds can be optimized via a medicinal chemistry ...
Samiksha Katiyar, Irina Kufareva, Ranjan Behera, Sarah M Thomas, Yuko Ogata, Michael Pollastri, Ruben Abagyan, Kojo Mensa-Wilmot   +7 more
doaj   +1 more source

Amygdalin may potentiate the effects of lapatinib on SK-BR-3 cancer cell death through increasing Bax expression [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان, 2023
Background and Aim: : HER-2 Positive breast cancer is one of the aggressive types of cancer and is resistant to chemotherapy drugs such as lapatinib .Amygdalin is a natural compound found in the seeds of fruits such as apricot, peache, apple and almond ...
Bahman Moradi poodeh
doaj