Results 51 to 60 of about 27,201 (202)

The Efficacy of Pyrotinib as a Third- or Higher-Line Treatment in HER2-Positive Metastatic Breast Cancer Patients Exposed to Lapatinib Compared to Lapatinib-Naive Patients: A Real-World Study

Frontiers in Pharmacology, 2021
Background: Pyrotinib is a novel irreversible pan-ErbB receptor tyrosine kinase inhibitor. Evidence of the efficacy of pyrotinib-based treatments for HER2-positive metastatic breast cancer (MBC) in patients exposed to lapatinib is limited.Methods: Ninety-
D. J Ouyang, D. J Ouyang, Q. T Chen, M. Anwar, N. Xie, Q. C. Ouyang, P. Z. Fan, L. Y. Qian, G. N. Chen, E. X. Zhou, L. Guo, X. W. Gu, B. N. Ding, X. H. Yang, L. P. Liu, C. Deng, Z. Xiao, J. Li, Y. Q. Wang, S. Zeng, Shouman Wang, Wenjun Yi   +21 more
doaj   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer

Neoplasia: An International Journal for Oncology Research, 2015
Heparanase (HPSE) is the dominant mammalian endoglycosidase and important tumorigenic, angiogenic, and pro-metastatic molecule. Highest levels of HPSE activity have been consistently detected in cells possessing highest propensities to colonize the brain,
Lixin Zhang, Jason A. Ngo, Michael D. Wetzel, Dario Marchetti   +3 more
doaj   +1 more source

Comparisons of lapatinib sensitivities and the baseline signalling proteins activities between parental and lapatinib-resistant subclones.

, 2014
A, Lapatinib sensitivity curves in the parental OE19 and two lapatinib-resistant (LR) subclones. The calculated values of IC50 of lapatinib were 200 nM in parental cells and >1,000 nM in two LR subclones.
Eirini Pectasides (515338), Yong Sang Hong (157544), Aaron R. Thorner (240349), Jihun Kim (10091), Cameron Fox (650742), Qiuping Ma (650743), Gabrielle S. Wong (650744), Adam J. Bass (257097), Paul Van Hummelen (2464627), Shouyong Peng (32247), Matthew D. Stachler (650745), Seung-Woo Hong (293235)   +11 more
core   +1 more source

The Discovery of Lapatinib (GW572016) [PDF]

Molecular Cancer Therapeutics, 2011
Commentary on: [David W. Rusnak, Karen Lackey, Karen Affleck, Edgar R. Wood, Krystal J. Alligood, Nelson Rhodes, Barry R. Keith, Doris M. Murray, W. Blaine Knight, Robert J. Mullin, and Tona M. Gilmer.
David, Rusnak, Tona M, Gilmer
openaire   +2 more sources

De‐Escalation of Neoadjuvant Treatment for HER2‐Positive Breast Cancer

International Journal of Cancer, Volume 159, Issue 10, Page 2393-2402, 15 November 2026.
ABSTRACT With improved prognosis in early HER2‐positive breast cancer, safely de‐escalating treatment is increasingly investigated to minimize overtreatment. This article focuses on neoadjuvant de‐escalation strategies for HER2‐positive breast cancer.
Yiyin Ma, Dedian Chen, Sheng Huang
wiley   +1 more source

Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer [PDF]

, 2015
Background Brain metastases are common in human epidermal growth factor receptor (Her)-2-positive breast cancer. Drug access to brain metastases and normal brain is key to management of cranial disease.
Woodley, L, Saleem, A, Palmieri, C, Kozlowski, K, Lowdell, C, Coombes, RC, Aboagye, EO, Kaneko, T, Kenny, LM, Searle, GE, Huiban, M, Murphy, PS, Lau, MR, Waldman, AD   +13 more
core   +1 more source

RETRACTED ARTICLE: Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain

Scientific Reports, 2021
Prognosis of patients with HER2+ breast-to-brain-metastasis (BBM) is dismal even after current standard-of-care treatments, including surgical resection, whole-brain radiation, and systemic chemotherapy.
Arunoday Bhan, Khairul Ansari, Mike Y. Chen, Rahul Jandial   +3 more
doaj   +1 more source

Frequency of Clinically Relevant Drug–Drug Interactions Between Tyrosine Kinase Inhibitors and Proton Pump Inhibitors in Patients With Cancer Using Real‐World Data

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Background Proton pump inhibitors (PPIs) raise stomach pH, leading to reduced bioavailability of many tyrosine kinase inhibitors (TKIs), thereby affecting treatment outcomes. To what extent this interaction occurs in clinical practice remains underexplored.
Grietje van Elp, Maikel Borg, Jens H. J. Bos, Catharina C. M. Schuiling‐Veninga, Katja Taxis, Frank G. A. Jansman   +5 more
wiley   +1 more source

Simulated structures of lapatinib-bound HLA system.

, 2015
Lapatinib-bound HLA-DRB1*01:01 (a-c), DRB1*07:01 (d-f) and DRB1*15:01 (g-i). (a), (d) and (g) Alignment of an initial structure (red) and a representative structure (blue).
Noriko Okudaira (758670), Takashi Izumi (758671), Katsunobu Hagihara (758669), Makoto Hirasawa (758668)   +3 more
core   +1 more source