Results 71 to 80 of about 27,201 (202)
Chemical structure of lapatinib, AEE788, and canertinib.
, 2013 Chemical structure of lapatinib, AEE788, and canertinib.
Samiksha Katiyar (379207) +7 more
core +1 more source
Lapatinib Induced Suicidal Death of Human Erythrocytes
Cellular Physiology and Biochemistry, 2015 Background/Aims: The human epidermal growth factor receptors tyrosine kinase inhibitor lapatinib has been shown to trigger suicidal death or apoptosis of tumor cells and is thus used for the treatment of malignancy.
Jens Zierle +3 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 38, 16 October 2026.This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti +10 more
wiley +1 more source
Advanced Science, Volume 13, Issue 58, 19 October 2026.This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li +14 more
wiley +1 more source
Lapatinib-induced acute generalized exanthematous pustulosis
, 2010 Acute generalized exanthematous pustulosis (AGEP) is a pustular eruption, mainly drug induced often accompanied by fever and neutrophilic leukocytosis presenting as scarlatiniform erythema over the flexures evolving into numerous tiny non follicular ...
Chembolli Lakshmi +2 more
core +1 more source
Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy
Advanced Science, Volume 13, Issue 58, 19 October 2026.A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao +10 more
wiley +1 more source
Lapatinib blocks hypertrophy development in ErbB2 transgenic mice.
, 2012 P4.5 male and female mice were treated with lapatinib via gavage for 8 days until P12.5 (n = 4–7 per genotype per treatment group per sex). (A) Increased heart weight to body weight ratio in ErbB2 transgenic mice at P12.5.
Polina Sysa-Shah (144392) +8 more
core +1 more source
Dacomitinib, but not lapatinib, suppressed progression in castration-resistant prostate cancer models by preventing HER2 increase [PDF]
, 2019 BackgroundDespite overexpression of the ErbB (EGFR/HER2/ErbB3/ErbB4) family in castration-resistant prostate cancer (CRPC), some inhibitors of this family, including the dual EGFR/HER2 inhibitor lapatinib, failed in Phase II clinical trials.
Leandro S. D’Abronzo +15 more
core +1 more source
Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells [PDF]
, 2010 Signaling through epidermal growth factor receptor (EGFR/ErbB) family members plays a very important role in regulating proliferation, development, and malignant transformation of mammary epithelial cells. ErbB family members are often over-expressed in
Tseng, Jen-Te
core +1 more source
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Multiple public databases, including TCGA, GEO, and TARGET, were utilized to comprehensively analyze pyridoxal phosphatase (PDXP) expression profiles across 34 cancer types. We further explored the associations of PDXP expression with clinicopathological features, tumor immune microenvironment, genomic heterogeneity, functional signaling ...
Yingjian Hu +5 more
wiley +1 more source