Results 51 to 60 of about 2,523 (255)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Research on the relationship between acoustic emission signal and material removal rate during fixed abrasive lapping

Jin'gangshi yu moliao moju gongcheng, 2017
Due to passivation and wear, fixed abrasive lapping pad needs to be conditioned.Material removal rate is one of the characteristic indexes to judge the condition of the lapping pad.The relationship between acoustic emission signal and material removal ...
TONG Haocheng, LI Jun, GUO Taiyu, MING Shun, ZHU Yongwei, ZUO Dunwen   +5 more
doaj  

Evaluation of Double-Sided Planetary Grinding Using Diamond Wheels for Sapphire Substrates

Crystals, 2018
Double-sided planetary grinding as an efficient and precise machining method is used for the rapid thinning and flattening process of sapphire substrate.
Lijuan Wang, Zhongwei Hu, Yiqing Yu, Xipeng Xu   +3 more
doaj   +1 more source

Analysis of kinematics of tool and work piece contact during lens processing

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2020
Using the first axiom of statics for equilibrium of a two forces system applied to points of a solid body, it was verified, that the pressure in the zone of contact of a tool with a lens during its abrasive processing by the grinding-free method is ...
A. S. Kozeruk, Y. L. Malpica, A. A. Sukhotski, V. I. Yurynok, M. I. Filonova, V. I. Shamkalovich   +5 more
doaj   +1 more source

INCIDENCE OF SHOULDER-TIP PAIN IN LAP. CHOLECYSTECTOMY NORMAL VERSUS LOW-PRESSURE PNEUMOPERITONEUM

Biological and Clinical Sciences Research Journal, 2023
Open cholecystectomy can lead to several post-operative complications. However, with the advent of minimal access surgery, these complications have decreased to a large extent. Nowadays, laparoscopic cholecystectomy is considered the gold standard for cholelithiasis.
openaire   +1 more source

Extrapolating echocardiographic determinants of elevated Left Atrial Pressure (LAP) to Cardiac Magnetic Resonance Imaging (CMR) to determine the best CMR correlate of elevated LAP [PDF]

Journal of Cardiovascular Magnetic Resonance, 2016
Background The ratio of the transmitral early inflow wave velocity (E wave velocity) and the velocity of the septal (or lateral) mitral annulus as measured by tissue Doppler (the e’ wave velocity) can be used to estimate left atrial pressure on echocardiographic examination.
Rao Edupuganti, Mohan, Vallurupalli, Srikanth, Bhatti, Sabha, Lensing, Shelly, Pandey, Tarun   +4 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source