Results 71 to 80 of about 7,634,771 (261)

Angiographical Identification of Intracranial, Atherosclerosis-Related, Large Vessel Occlusion in Endovascular Treatment [PDF]

, 2019
Identification of intracranial, atherosclerosis-related, large vessel occlusion (ICAS-LVO) is important to set up an optimal endovascular treatment strategy, as most ICAS-LVOs require specific endovascular modalities for efficient recanalization. However,
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core   +1 more source

Asymmetrical Bioimpedance in the Anterior Circulation for Urgent Stratification of suspected Stroke (ABACUS Stroke): study protocol for a diagnostic accuracy study

Diagnostic and Prognostic Research, 2020
Background Early identification and treatment of stroke improve outcome. Ischaemic stroke due to large vessel occlusion (LVO) benefits from time-critical thrombectomy but this is only available in highly specialised healthcare services.
Christopher I. Price, Lisa Shaw, Anand Dixit, Sara Graziadio, Clare Lendrem, Dipayan Mitra, Helen Rodgers, Lou Sutcliffe, Phil White   +8 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Predictive value of modifications of the prehospital rapid arterial occlusion evaluation scale for large vessel occlusion in patients with acute stroke

, 2017
Prehospital clinical scales to identify patients with acute stroke with a large vessel occlusion and direct them to an endovascular-capable stroke center are needed.
Gorchs, Montse, Querol, Marisol, Millán, Mònica, Carrera, David, Dávalos, Antoni, Jiménez, Xavier, Pérez de la Ossa, Natalia, Campbell, Bruce, Cortés Martínez, Jordi   +8 more
core   +1 more source

Large-Vessel Dilatation in Giant Cell Arteritis: A Different Subset of Disease? [PDF]

, 2018
To compare patients with large-vessel giant cell arteritis (LV-GCA) characterized by wall thickening, stenosis, and/or occlusion of subclavian arteries to those with subclavian ...
Muratore, Francesco, Kermani, Tanaz A, Carlo Salvarani, Warrington, Kenneth J, Matteson, Eric L, Kenneth J. Warrington, Tanaz A. Kermani, Francesco Muratore, Eric L. Matteson, Koster, Matthew J, Cynthia S. Crowson, Crowson, Cynthia S, Salvarani, Carlo, Matthew J. Koster   +13 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Effect of Intravenous Tirofiban Versus Placebo on First‐Pass Successful Reperfusion in Endovascular Stroke Thrombectomy: Insights From the RESCUE BT Randomized Clinical Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background First‐pass successful reperfusion (FPSR), defined as a successful/complete reperfusion achieved after a single thrombectomy pass, is predictive of favorable outcome in patients with acute ischemic stroke with large‐vessel occlusion.
Junjie Yuan, Hanming Ge, Zhaojun Tao, Huijie An, Qin Han, Jeffrey L. Saver, Thanh N. Nguyen, Simin Zhou, An Mao, Yuelu Wu, Raul Gomes Nogueira, Yaxuan Sun, Shunfu Jiang, Liping Wei, Xinmin Fu, Yongjie Bai, Shunyu Yang, Wei Hu, Guling Zhang, Chengde Pan, Shuai Zhang, Lin Qiao, Qiong Chen, Hongfei Sang, Zhongming Qiu, Fengfu Wu, Mingze Chang, Zhongfan Ruan   +27 more
doaj   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Geometry‐Encoded Soft Strain Sensing via Liquid‐Metal Transmission Lines

Advanced Science, EarlyView.
This study presents a liquid‐metal transmission‐line strain sensor that achieves intrinsic decoupling by encoding axial elongation into propagation delay. The time‐domain readout remains stable under complex off‐axis. This enables reliable, repeatable, real‐time elongation measurement in dynamic, multiaxial loading environments for wearable electronics,
Zhang Liu, Fengdeng Jin, Wenxuan Shi, Meng She, Ziqi Meng, Miao Fang, Yixin Zhang, Qianwen Dong, Wandi Yang, Lei Shi, Xujia Zhao, Feng Zhou, Bin Yao   +12 more
wiley   +1 more source