Results 21 to 30 of about 3,266,852 (276)

Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis

IUCrJ, 2021
Cofactor-independent urate oxidase (UOX) is an ∼137 kDa tetrameric enzyme essential for uric acid (UA) catabolism in many organisms. UA is first oxidized by O2 to dehydroisourate (DHU) via a peroxo intermediate.
Lindsay McGregor, Tamás Földes, Soi Bui, Martine Moulin, Nicolas Coquelle, Matthew P. Blakeley, Edina Rosta, Roberto A. Steiner   +7 more
doaj   +1 more source

Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry [PDF]

, 2018
Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30.
Garden, O A, Pittaway, R, Polton, G, Priestnall, S L, Scurrell, E J, Suárez-Bonnet, A, Szladovits, B, Wu, Y   +7 more
core   +2 more sources

Fostering landscape immunity to protect human health: A science‐based rationale for shifting conservation policy paradigms

Conservation Letters, 2022
Anthropogenic land use change is a major driver of zoonotic pathogen spillover from wildlife to humans. According to the land use‐induced spillover model, land use change alters environmental conditions that in turn alter the dynamics between zoonotic ...
Jamie K. Reaser, Brooklin E. Hunt, Manuel Ruiz‐Aravena, Gary M. Tabor, Jonathan A. Patz, Daniel J. Becker, Harvey Locke, Peter J. Hudson, Raina K. Plowright   +8 more
doaj   +1 more source

Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides [PDF]

, 2012
Copyright @ 2012 John Wiley & SonsThe miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory ...
Ballabio, E, Benner, MF, Lawrie, CH, Saunders, NJ, Tensen, CP, van Kester, MS, Vermeer, MH, Willemze, R   +7 more
core   +1 more source

Anaplastic large cell lymphoma in paediatric and young adult patients. [PDF]

, 2016
Anaplastic large cell lymphoma (ALCL) is a heterogeneous disease of debateable origin that, in children, is largely anaplastic lymphoma kinase (ALK) positive with aberrant ALK activity induced following the formation of chromosomal translocations. Whilst
Agnelli, Ait-Tahar, Ait-Tahar, Alexander, Ambrogio, Bai, Bai, Bartlett, Benharroch, Bonzheim, Brugieres, Brugieres, Brugieres, Brugieres, Chiarle, Chiarle, Cools, Crescenzo, Damm-Welk, Damm-Welk, Deley, Deley, Duvic, Elias, Eyre, Falini, Falini, Fanale, Feldman, Feldman, Gambacorti Passerini, Gambacorti Passerini, Gascoyne, Hanahan, Hoareau-Aveilla, Hoch, Katayama, Kempf, Kenner, Kinney, Laimer, Laly, Lamant, Lamant, Lamant, Lamant, Laurent, Laurent, Laver, Leventaki, Liang, Lowe, Malcolm, Marzec, Marzec, Marzec, Mason, McDonnell, Merkel, Merkel, Mori, Morris, Mosse, Moti, Mussolin, Mussolin, Parrilla Castellar, Passoni, Passoni, Pileri, Pro, Pulford, Raica, Richly, Rolland, Rosenwald, Rosolen, Ruf, Salaverria, Savage, Schmitz, Seidemann, Sibon, Slupianek, Stein, Suzuki, Swerdlow, Tanaka, Tanaka, Tort, Touriol, Trinei, Turner, Turner, Vasmatzis, Vassallo, Wencker, Willemze, Williams, Williams, Woessmann, Woessmann, Wrobel, Ye, Youssif, Zhang, Zhang   +106 more
core   +1 more source

Large Cell Carcinoma [PDF]

, 2020
Originally large cell carcinoma was defined by the absence of visible glandular or squamoid features. Due to immunohistochemistry introduced into NSCLC diagnosis, this exclusion was extended. Solid carcinomas negative for either TTF1 or p40 without visible glandular or squamoid differentiation are now large cell carcinomas.
Helmut Popper, Bruno Murer
openaire   +2 more sources

Induction of NETosis in ovine colostral PMN upon exposure to Neospora caninum tachyzoites

Frontiers in Veterinary Science, 2023
Colostrum is one of the most important factors influencing the health and development of mammalian neonates. It is well-established that leukocytes, including polymorphonuclear neutrophils (PMN), migrate from the mother to the infant via colostrum uptake.
Lukas Demattio, Ivan Conejeros, Daniela Grob, Ulrich Gärtner, Anja Taubert, Carlos Hermosilla, Axel Wehrend   +6 more
doaj   +1 more source

Macrophage elastase derived from adventitial macrophages modulates aortic remodeling

Frontiers in Cell and Developmental Biology, 2023
Abdominal aortic aneurysm (AAA) is pathologically characterized by intimal atherosclerosis, disruption and attenuation of the elastic media, and adventitial inflammatory infiltrates.
Yajie Chen, Yajie Chen, Xiawen Yang, Shuji Kitajima, Longquan Quan, Yao Wang, Maobi Zhu, Enqi Liu, Liangxue Lai, Liangxue Lai, Haizhao Yan, Haizhao Yan, Haizhao Yan, Jianglin Fan, Jianglin Fan   +14 more
doaj   +1 more source

Preoperative CYFRA 21-1 and CEA as Prognostic Factors in Patients with Stage I Non-Small Cell Lung Cancer [PDF]

, 2008
Objective: To validate the prognostic value of preoperative levels of CYFRA 21-1, CEA and the corresponding tumor marker index (TMI) in patients with stage I non-small cell lung cancer (NSCLC). Methods: Two hundred forty stage I NSCLC patients (80 in pT1
Ankerst, Donna Pauler, Blankenburg, Florian, Gruber, Christine, Hatz, Rudolf, Nagel, Dorothea, Reinmiedl, Judith, Seidel, Dietrich, Stieber, Petra   +7 more
core   +1 more source

α-Smooth muscle actin expression in cancerassociated fibroblasts in canine epithelial tumors [PDF]

, 2017
Tumor tissues contain not only cancer cells but also other cell types including, fibroblasts, immune cells, and endothelial cells, which interact with cancer cells.
Hoshino, Yuki, Izumi, Yusuke, Takagi, Satoshi, Yoshimoto, Sho   +3 more
core   +1 more source