Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non–small cell carcinoma [PDF]
BackgroundMost patients with pathologic stage Ia non–small cell lung carcinoma have a good prognosis, and adjuvant chemotherapy is currently not being used in the management of this stage of the disease.
Toshihiko Iizasa +15 more
core +1 more source
Primary large cell neuroendocrine carcinoma of the renal pelvis: a case report [PDF]
We report a case of primary large cell neuroendocrine carcinoma of the renal pelvis, diagnosed in a 79-year-old man. The abdominal computed tomography showed a solid, vegetant lesion in the left renal pelvis, conditioning marked hydronephrosis.
Dell'Orto P. G. +9 more
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Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation [PDF]
High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare.
Guimarães, Lucinda Calheiros +3 more
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Tarlatamab for Large Cell Neuroendocrine Carcinoma in a Young Adult: A Case Report
A 20-year-old man with metastatic large cell neuroendocrine carcinoma of the lung was treated with the delta-like ligand 3–targeting bispecific T cell engager, tarlatamab. Treatment was complicated by transient cytokine release syndrome but resulted in a
Shetal A. Patel, MD, PhD +7 more
doaj +1 more source
The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo [PDF]
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical ...
Eva Juengel +13 more
core +1 more source
Pure large cell neuroendocrine carcinoma of the bladder without urological symptoms
Neuroendocrine carcinoma is one of the uncommonly seen pathologies of the urinary bladder. Macroscopic hematuria is frequently encountered symptom in patients with neuroendocrine carcinoma.
Ekrem Akdeniz +4 more
doaj +1 more source
Primary large cell neuroendocrine carcinoma of the larynx
Neuroendocrine tumours (NETs) can arise in most organs of the body but are most frequently recorded in the gastrointestinal tract or lungs. They are rarely found in the head and neck region. The commonest site in the head and neck region is in the larynx.
N. Maithrea +3 more
doaj +1 more source
Neuroendocrine tumors commonly involve the respiratory and gastrointestinal systems. Primary genitourinary neuroendocrine tumors are rare, accounting for less than 1% of all bladder carcinomas. Four histopathologic subtypes have been described.
Ali Zakaria +3 more
doaj +1 more source
Large-cell neuroendocrine carcinoma (LCNEC) of the lung is a high-grade carcinoma belonging to the neuroendocrine tumors of the lung and is different from typical lung large-cell carcinoma.
Francesca Aroldi +8 more
doaj +1 more source
Carrier cell-mediated cell lysis of squamous cell carcinoma by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus [PDF]
The squamous cell carcinoma antigen (SCCA) serves as a serological marker for squamous cell carcinomas. Molecular cloning of the SCCA genomic region has revealed the presence of two tandemly arrayed genes, SCCA1 and SCCA2.
Yoshiyuki Koyama +7 more
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