Results 121 to 130 of about 631,512 (303)

All-solid aperiodic Large Pitch Fibers for operation in high power regime

, 2015
International audienceThis communication intends to summarize the recent strides carried out by the study of original Very Large Mode Area fibers (VLMA) that offer remarkable beam qualities.
Benoit, Aurélien, Darwich, Dia, Dauliat, Romain, Grimm, Stephan, Jamier, Raphaël, Roy, Philippe, Salin, François, Schuster, Kay   +7 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Compact 85 fs frequency doubled 810 nm fiber system with 60 mW of average power

, 2005
We demonstrate a sub-100 fs frequency doubled fiber laser operating at 810 nm. The laser produces 60 mW of average power at a repetition rate of 50 MHz.
Clowes, J., Godfrey, I., Grudinin, A.B., Soh, D.B.S.   +3 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Single Trench Fiber-Enabled High-Power Fiber Laser

Photonics
As a novel design of large-mode-area fiber, the single trench fiber (STF) providing high higher-order-mode suppression with a large mode area for the fundamental mode shows potential for high-power and high-brightness applications.
Yi An, Fengchang Li, Huan Yang, Xiao Chen, Liangjin Huang, Zhiping Yan, Min Jiang, Baolai Yang, Peng Wang, Zhiyong Pan, Zongfu Jiang, Pu Zhou   +11 more
doaj   +1 more source

Ultra large mode area fibers with aperiodic cladding structure for high power single mode lasers

, 2015
International audienceThis communication presents the latest designs, fabrication steps and first results of large mode area fibres with aperiodic cladding structure for high power singlemode emission.
Benoit, Aurélien, Darwich, Dia, Dauliat, Romain, Grimm, Stephan, Jamier, Raphaël, Kobelke, Jens, Roy, Philippe, Salin, François, Schuster, Kay   +8 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Enhanced amplified spontaneous emission via splitted strong coupling mode in large-area plasmonic cone lattices

Opto-Electronic Science
Periodic metal nanoarrays serving as cavities can support directional-tunable amplified spontaneous emission that goes beyond the diffraction limit due to the hybrid states of surface plasmons and Bloch surface waves.
Jiazhi Yuan, Jiang Hu, Yan Zheng, Hao Wei, Jiamin Xiao, Yi Wang, Xuchao Zhao, Ye Xiang, Yong Lei, Wenxin Wang   +9 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source