Results 121 to 130 of about 618,573 (283)

All-solid aperiodic Large Pitch Fibers for operation in high power regime

, 2015
International audienceThis communication intends to summarize the recent strides carried out by the study of original Very Large Mode Area fibers (VLMA) that offer remarkable beam qualities.
Benoit, Aurélien, Darwich, Dia, Dauliat, Romain, Grimm, Stephan, Jamier, Raphaël, Roy, Philippe, Salin, François, Schuster, Kay   +7 more
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Ultra large mode area fibers with aperiodic cladding structure for high power single mode lasers

, 2015
International audienceThis communication presents the latest designs, fabrication steps and first results of large mode area fibres with aperiodic cladding structure for high power singlemode emission.
Benoit, Aurélien, Darwich, Dia, Dauliat, Romain, Grimm, Stephan, Jamier, Raphaël, Kobelke, Jens, Roy, Philippe, Salin, François, Schuster, Kay   +8 more
core   +1 more source

Compact 85 fs frequency doubled 810 nm fiber system with 60 mW of average power

, 2005
We demonstrate a sub-100 fs frequency doubled fiber laser operating at 810 nm. The laser produces 60 mW of average power at a repetition rate of 50 MHz.
Clowes, J., Godfrey, I., Grudinin, A.B., Soh, D.B.S.   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Single Trench Fiber-Enabled High-Power Fiber Laser

Photonics
As a novel design of large-mode-area fiber, the single trench fiber (STF) providing high higher-order-mode suppression with a large mode area for the fundamental mode shows potential for high-power and high-brightness applications.
Yi An, Fengchang Li, Huan Yang, Xiao Chen, Liangjin Huang, Zhiping Yan, Min Jiang, Baolai Yang, Peng Wang, Zhiyong Pan, Zongfu Jiang, Pu Zhou   +11 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Enhanced amplified spontaneous emission via splitted strong coupling mode in large-area plasmonic cone lattices

Opto-Electronic Science
Periodic metal nanoarrays serving as cavities can support directional-tunable amplified spontaneous emission that goes beyond the diffraction limit due to the hybrid states of surface plasmons and Bloch surface waves.
Jiazhi Yuan, Jiang Hu, Yan Zheng, Hao Wei, Jiamin Xiao, Yi Wang, Xuchao Zhao, Ye Xiang, Yong Lei, Wenxin Wang   +9 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source