Results 101 to 110 of about 7,625,750 (291)

CytoGPS: A large-scale karyotype analysis of CML data

Cancer Genetics, 2020
Karyotyping, the practice of visually examining and recording chromosomal abnormalities, is commonly used to diagnose diseases of genetic origin, including cancers. Karyotypes are recorded as text written in the International System for Human Cytogenetic Nomenclature (ISCN).
Zachary B. Abrams, Suli Li, Lin Zhang, Caitlin E. Coombes, Philip R.O. Payne, Nyla A. Heerema, Lynne V. Abruzzo, Kevin R. Coombes   +7 more
openaire   +3 more sources

Task-related edge density (TED) - a new method for revealing large-scale network formation in fMRI data of the human brain

, 2015
The formation of transient networks in response to external stimuli or as a reflection of internal cognitive processes is a hallmark of human brain function. However, its identification in fMRI data of the human brain is notoriously difficult.
Bartels, Andreas, Buschmann, Tilo, Lohmann, Gabriele, Margulies, Daniel, Scheffler, Klaus, Stelzer, Johannes, Zuber, Verena   +6 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

DEVELOPMENT OF LEARNING MODULE MENGOLAH DATA DENGAN MICROSOFT ACCESS 2003 ON COMPUTER SKILLS AND MANAGEMENTINFORMATION LESSONS IN SMK NEGERI 2 SUKOHARJO [PDF]

, 2011
This study aims to: 1) Make learning modules process the data with Microsoft Access 2003, 2) Examine the feasibility of learning module to process data with Microsoft Access 2003 as a medium of teaching in SMK Negeri 2 Sukoharjo, and 3) Determine the ...
Swasono, Endah Widiyanti
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Fast principal component analysis of large-scale genome-wide data.

PLoS ONE, 2014
Principal component analysis (PCA) is routinely used to analyze genome-wide single-nucleotide polymorphism (SNP) data, for detecting population structure and potential outliers.
Gad Abraham, Michael Inouye
doaj   +1 more source

Probing signatures of bounce inflation with current observations

, 2018
The aim of this paper is to probe the features of the bouncing cosmology with the current observational data. Basing on bounce inflation model, with high derivative term, we propose a general parametrization of primordial power spectrum which includes ...
Li, Hong, Ni, Shulei, Qiu, Taotao, Zhang, Xin, Zheng, Wei   +4 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Biclustering analysis for large scale data

, 2012
High-Throughput-Technologien stellen einen Durchbruch in der experimentellen Molekularbiologie dar. Sie ermöglichen eine Einsicht in die molekularen Mechanismen der Zelle, die mit traditionellen Ansätzen nicht zu erforschen sind. Mithilfe von differenzierten statistischen und computergestützen Methoden können wertvolle Informationen aus diesen ...
openaire   +2 more sources