Results 41 to 50 of about 356,130 (291)

Simulation Environment for Scalability and Performance Analysis in Hierarchically Organized IoT Systems

Telfor Journal, 2022
The accelerated development of technologies, especially in the field of telecommunications, ease the integration of embedded devices within various IoT applications.
H Turkmanović, I. Popović, Z. Čiča, D. Drajić   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A NOT operation on Majorana qubits with mobilizable solitons in an extended Su–Schrieffer–Heeger model

New Journal of Physics, 2015
Coupling Majorana qubits with other qubits is absolutely essential for storing, manipulating and transferring information for topological quantum computing.
Ye Xiong, Peiqing Tong
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Simphony: simulating large-scale, rhythmic data

PeerJ, 2018
Simulated data are invaluable for assessing a computational method’s ability to distinguish signal from noise. Although many biological systems show rhythmicity, there is no general-purpose tool to simulate large-scale, rhythmic data.
Singer, Jordan M, Fu, Darwin Y, Hughey, Jacob J   +2 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Two-Dimensional Particle Assembly Based on the Synchronized Evolution of Centrosymmetric Off-Axis Acoustic Vortexes

Engineering
Acoustic-vortex (AV) tweezers ensure stable particle trapping at a zero-pressure center, while particle assembly between two vortex cores is still prevented by the high-potential barrier.
Ning Ding, Gepu Guo, Juan Tu, Dong Zhang, Qingyu Ma   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

New Trends in Large Scale Distributed Systems Simulation

Journal of Algorithms & Computational Technology, 2011
In this paper we present recent developments in the domain of modeling and simulation of large scale distributed systems (LSDS). Such systems possess features that include resource sharing, openness, concurrency, scalability, fault-tolerance, and ...
Ciprian Dobre, Florin Pop, Valentin Cristea   +2 more
doaj   +1 more source

Large-eddy simulations of marine boundary-layer clouds associated with cold air outbreaks during the ACTIVATE campaign-part 1: Case setup and sensitivities to large-scale forcings [PDF]

, 2021
Xiangyu Li, Hailong Wang, Jingyi Chen, Satoshi Endo, Geet George, Brian Cairns, Seethala Chellappan, Xubin Zeng, Simon Kirschler, Christiane Voigt, Armin Sorooshian, Ewan Crosbie, Gao Chen, R. A. Ferrare, William I. Gustafson, Johnathan W. Hair, Mary M. Kleb, Hongyu Liu, Richard H. Moore, David Painemal, Claire Robinson, Amy Jo Scarino, Michael A. Shook, Taylor Shingler, Kenneth L. Thornhill, Florian Tornow, Heng Xiao, Luke D. Ziemba, Paquita Zuidema   +28 more
openalex   +1 more source