Results 61 to 70 of about 13,162,473 (330)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Prospects for large-scale financial systems simulation

, 2011
As the 21st century unfolds, we find ourselves having to control, support, manage or otherwise cope with large-scale complex adaptive systems to an extent that is unprecedented in human history.
Bullock, Seth
core   +1 more source

Two-Dimensional Particle Assembly Based on the Synchronized Evolution of Centrosymmetric Off-Axis Acoustic Vortexes

Engineering
Acoustic-vortex (AV) tweezers ensure stable particle trapping at a zero-pressure center, while particle assembly between two vortex cores is still prevented by the high-potential barrier.
Ning Ding, Gepu Guo, Juan Tu, Dong Zhang, Qingyu Ma   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Large scale simulation of turbulence using a hybrid spectral/finite difference solver [PDF]

, 2009
Performing Direct Numerical Simulation (DNS) of turbulence on large-scale systems (offering more than 1024 cores) has become a challenge in high performance computing.
Bodart, Julien, Cazalbou, Jean-Bernard, Joly, Laurent   +2 more
core  

Large-eddy simulation of turbulent flow over a rough surface [PDF]

, 2004
A family of wall models is proposed that exhibits more satisfactory performance than previous models for the large-eddy simulation (LES) of the turbulent boundary layer over a rough surface.The time and horizontally averaged statistics such as mean ...
Robins, Alan, Xie, Z, Voke, Peter R., Voke, PR, Hayden, Paul, Robins, Alan G., Xie, Zhengtong   +6 more
core   +1 more source

New Trends in Large Scale Distributed Systems Simulation

Journal of Algorithms & Computational Technology, 2011
In this paper we present recent developments in the domain of modeling and simulation of large scale distributed systems (LSDS). Such systems possess features that include resource sharing, openness, concurrency, scalability, fault-tolerance, and ...
Ciprian Dobre, Florin Pop, Valentin Cristea   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Synergistic sonothrombolysis based on coaxial confocal dual-frequency focused ultrasound and vortex beams

Ultrasonics Sonochemistry
Focused ultrasound (FU) acts as a non-invasive targeted therapy for thrombus dissolution, leveraging its mechanical and cavitation effects. The thrombolysis efficiency can be markedly improved with the incorporation of an assisted focused acoustic vortex
Tinghui Meng, Zelin Sheng, Tingzhen Feng, Gepu Guo, Qingyu Ma   +4 more
doaj   +1 more source

Simulation Environment for Scalability and Performance Analysis in Hierarchically Organized IoT Systems

Telfor Journal, 2022
The accelerated development of technologies, especially in the field of telecommunications, ease the integration of embedded devices within various IoT applications.
H Turkmanović, I. Popović, Z. Čiča, D. Drajić   +3 more
doaj   +1 more source