Results 51 to 60 of about 1,960,715 (319)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Curvature-Influenced Electrocatalytic NRR Reactivity by Heme-like FeN4-Site on Carbon Materials
MoleculesTwo-dimensional carbon materials and their derivatives are widely applied as promising electrocatalysts and supports of single-atom sites. Theoretical investigations of 2D carbon materials are usually based on planar models, yet ignore local curvature ...
Yajie Meng +6 more
doaj +1 more source
Testing the reliability of weak lensing cluster detections [PDF]
, 2007 We study the reliability of dark-matter halo detections with three different linear filters applied to weak-lensing data. We use ray-tracing in the multiple lens-plane approximation through a large cosmological simulation to construct realizations of ...
Arnaboldi +44 more
core +3 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Simphony: simulating large-scale, rhythmic data
PeerJ, 2018 Simulated data are invaluable for assessing a computational method’s ability to distinguish signal from noise. Although many biological systems show rhythmicity, there is no general-purpose tool to simulate large-scale, rhythmic data.
Singer, Jordan M +2 more
openaire +3 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
EngineeringAcoustic-vortex (AV) tweezers ensure stable particle trapping at a zero-pressure center, while particle assembly between two vortex cores is still prevented by the high-potential barrier.
Ning Ding +4 more
doaj +1 more source
New Journal of Physics, 2015 Coupling Majorana qubits with other qubits is absolutely essential for storing, manipulating and transferring information for topological quantum computing.
Ye Xiong, Peiqing Tong
doaj +1 more source
Amplification of large-scale magnetic field in nonhelical magnetohydrodynamics
, 2017 It is typically assumed that the kinetic and magnetic helicities play a crucial role in the growth of large-scale dynamo. In this paper we demonstrate that helicity is not essential for the amplification of large-scale magnetic field.
Kumar, Rohit, Verma, Mahendra K.
core +3 more sources