Results 61 to 70 of about 1,960,715 (319)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

New Trends in Large Scale Distributed Systems Simulation

Journal of Algorithms & Computational Technology, 2011
In this paper we present recent developments in the domain of modeling and simulation of large scale distributed systems (LSDS). Such systems possess features that include resource sharing, openness, concurrency, scalability, fault-tolerance, and ...
Ciprian Dobre, Florin Pop, Valentin Cristea   +2 more
doaj   +1 more source

Moist Convection and the Thermal Stratification of the Extratropical Troposphere [PDF]

, 2008
Simulations with an aquaplanet general circulation model show that sensible and latent heat transport by large-scale eddies influences the extratropical thermal stratification over a wide range of climates, even in relatively warm climates with small ...
O'Gorman, Paul A., Schneider, Tapio
core   +1 more source

NYUS.2: an automated machine learning prediction model for the large-scale real-time simulation of grapevine freezing tolerance in North America [PDF]

, 2023
Hongrui Wang, Gaurav D. Moghe, Alisson P. Kovaleski, Markus Keller, Timothy E. Martinson, A. Harrison Wright, Jeffrey L. Franklin, Andréanne Hébert-Haché, Caroline Provost, Michael D. Reinke, Amaya Atucha, Michael G. North, Jennifer P Russo, Pierre Helwi, Michela Centinari, Jason P. Londo   +15 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Synergistic sonothrombolysis based on coaxial confocal dual-frequency focused ultrasound and vortex beams

Ultrasonics Sonochemistry
Focused ultrasound (FU) acts as a non-invasive targeted therapy for thrombus dissolution, leveraging its mechanical and cavitation effects. The thrombolysis efficiency can be markedly improved with the incorporation of an assisted focused acoustic vortex
Tinghui Meng, Zelin Sheng, Tingzhen Feng, Gepu Guo, Qingyu Ma   +4 more
doaj   +1 more source

Energy Spectra of Quantum Turbulence: Large-scale Simulation and Modeling [PDF]

, 2011
In $2048^3$ simulation of quantum turbulence within the Gross-Pitaevskii equation we demonstrate that the large scale motions have a classical Kolmogorov-1941 energy spectrum E(k) ~ k^{-5/3}, followed by an energy accumulation with E(k) ~ const at k ...
A. N. Kolmogorov, A. N. Kolmogorov, L. Pitaevskii, Makoto Tsubota, Masahiko Machida, Narimasa Sasa, Oleksii Rudenko, Takuma Kano, U. Frisch, V. B. Eltsov, V. S. L’vov, Victor S. L’vov   +11 more
core   +2 more sources

Large-eddy simulations of marine boundary-layer clouds associated with cold air outbreaks during the ACTIVATE campaign-part 1: Case setup and sensitivities to large-scale forcings [PDF]

, 2021
Xiangyu Li, Hailong Wang, Jingyi Chen, Satoshi Endo, Geet George, Brian Cairns, Seethala Chellappan, Xubin Zeng, Simon Kirschler, Christiane Voigt, Armin Sorooshian, Ewan Crosbie, Gao Chen, R. A. Ferrare, William I. Gustafson, Johnathan W. Hair, Mary M. Kleb, Hongyu Liu, Richard H. Moore, David Painemal, Claire Robinson, Amy Jo Scarino, Michael A. Shook, Taylor Shingler, Kenneth L. Thornhill, Florian Tornow, Heng Xiao, Luke D. Ziemba, Paquita Zuidema   +28 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A first estimate of radio halo statistics from large-scale cosmological simulation

, 2012
We present a first estimate based on a cosmological gasdynamics simulation of galaxy cluster radio halo counts to be expected in forthcoming low-frequency radio surveys.
Ackermann, Arnaud, Bertschinger, Bialek, Bonafede, Brunetti, Brunetti, Buote, Cassano, Cohen, Deiss, Dolag, Dubey, Fryxell, Govoni, Heitmann, Jarvis, Jeltema, Kempner, Kempner, Keshet, Komatsu, Kuo, Kushnir, Liang, Lukić, P. M. Ricker, P. M. Sutter, Paul, Petrosian, Ricker, Ricker, Röttgering, Schlickeiser, Stanek, Vazza, Venturi, Warren, Wolfe   +38 more
core   +2 more sources