Results 131 to 140 of about 179,347,395 (254)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Numerical Simulations of the Formation

, 2007
Contents 1 Introduction 1 1.1 General relativity and cosmology . . . . . . . . . . . . . . . . . . . 2 1.2 The Friedmann models . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.2.1 Perfect fluid models . . . . . . . . . . . . . . . . . . . . . . . .
Of Large-Scale Structure, Ludwig-maximilians-universität München   +1 more
core  

Testing Inflation with Large Scale Structure: Connecting Hopes with Reality

, 2014
The statistics of primordial curvature fluctuations are our window into the period of inflation, where these fluctuations were generated. To date, the cosmic microwave background has been the dominant source of information about these perturbations ...
Anže Slosar, Valentin Assassi, Roland de Putter, Zhiqi Huang, Amir Hajian, Donghui Jeong, Dragan Huterer, Matias Zaldarriaga, Alexander van Engelen, P. Daniel Meerburg, Kendrick Smith, Marilena Loverde, Eva Silverstein, Neal Dalal, Sarah Shandera, J. Richard Bond, Daniel Green, George Stein, Olivier Doré, Matthew C. Johnson, Tobias Baldauf, Chris Hirata, Jonathan Braden, Elisabeth Krause, Marcelo Alvarez, Joel Meyers, Leonardo Senatore, Takeshi Kobayashi   +27 more
core   +1 more source

Cross-Frequency Dependence Overlap in the Chinese A-Share Dependence Network. [PDF]

Entropy (Basel)
Mo J, Zhang J, Chen S, Zhang H.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Large Scale Structure of the Universe from Blue Primordial Perturbation Spectra

, 1995
Mollerach, S., Colafrancesco, S, Moscardini, L, Mei, S, DE GASPERIS, GIANCARLO, Lucchin, F, Matarrese, S, VITTORIO, NICOLA   +7 more
core   +1 more source

Outputs of generative diffusion models are often unattributable. [PDF]

Nat Commun
Dai Z, Gifford DK.
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source