Results 71 to 80 of about 424,562 (307)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

The Kullback–Leibler Divergence and the Convergence Rate of Fast Covariance Matrix Estimators in Galaxy Clustering Analysis

The Astrophysical Journal
We present a method to quantify the convergence rate of the fast estimators of the covariance matrices in the large-scale structure analysis. Our method is based on the Kullback–Leibler (KL) divergence, which describes the relative entropy of two ...
Zhigang Li, Zhejie Ding, Yu Yu, Pengjie Zhang   +3 more
doaj   +1 more source

Corrected SFD: A More Accurate Galactic Dust Map with Minimal Extragalactic Contamination

The Astrophysical Journal, 2023
The widely used Milky Way dust-reddening map, the Schlegel–Finkbeiner–Davis (SFD) map, was found to contain extragalactic large-scale structure (LSS) imprints.
Yi-Kuan Chiang
doaj   +1 more source

LARGE-SCALE STRUCTURE OF THE UNIVERSE AS A COSMIC STANDARD RULER [PDF]

, 2009
We propose to use the large-scale structure (LSS) of the universe as a cosmic standard ruler. This is possible because the pattern of large-scale distribution of matter is scale-dependent and does not change in comoving space during the linear-regime ...
Changbom Park, Young-Rae kIM
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Lagrangian Perturbation Theory for Biased Tracers: Significance of the Number Conservation

The Astrophysical Journal
The Lagrangian perturbation theory provides a simple yet powerful way of computing the nonlinear matter power spectrum, and it has been applied to biased tracers such as halos and galaxies.
Peter Espenshade, Jaiyul Yoo
doaj   +1 more source

Identification of Superclusters and Their Properties in the Sloan Digital Sky Survey Using the WHL Cluster Catalog

The Astrophysical Journal, 2023
Superclusters are the largest massive structures in the cosmic web, on tens to hundreds of megaparsec scales. They are the largest assembly of galaxy clusters in the Universe.
Shishir Sankhyayan, Joydeep Bagchi, Elmo Tempel, Surhud More, Maret Einasto, Pratik Dabhade, Somak Raychaudhury, Ramana Athreya, Pekka Heinämäki   +8 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). XVIII. The Dark Matter Halo Mass of Quasars at z ∼ 6

The Astrophysical Journal, 2023
We present, for the first time, dark matter halo (DMH) mass measurement of quasars at z ∼ 6 based on a clustering analysis of 107 quasars. Spectroscopically identified quasars are homogeneously extracted from the Hyper Suprime-Cam Strategic Survey ...
Junya Arita, Nobunari Kashikawa, Yoshiki Matsuoka, Wanqiu He, Kei Ito, Yongming Liang, Rikako Ishimoto, Takehiro Yoshioka, Yoshihiro Takeda, Kazushi Iwasawa, Masafusa Onoue, Yoshiki Toba, Masatoshi Imanishi   +12 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source