Results 71 to 80 of about 430,581 (306)
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Testing the Strong Equivalence Principle. II. Relating the External Field Effect in Galaxy Rotation Curves to the Large-scale Structure of the Universe [PDF]
, 2021 Kyu‐Hyun Chae +4 more
openalex +1 more source
The Astrophysical JournalWe apply a halo velocity bias model, γ _f , within the Aemulus simulation suite for General Relativity to investigate its efficacy in identifying the signature of assembly bias and Modified Gravity (MG).
Yirong Wang +3 more
doaj +1 more source
Is the Lambda CDM Model Consistent with Observations of Large-Scale Structure?
, 2000 The claim that large-scale structure data independently prefers the Lambda Cold Dark Matter model is a myth. However, an updated compilation of large-scale structure observations cannot rule out Lambda CDM at 95% confidence. We explore the possibility of
AE Evrard +12 more
core +2 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
General Relativity and the Bulk-flow Puzzle
The Astrophysical JournalBulk peculiar flows are commonplace in the Universe, with many surveys reporting their presence on scales spanning between few hundred and several hundred Mpc.
Christos G. Tsagas
doaj +1 more source
The Astrophysical Journal, 2023 The apparent shape of galaxy clustering depends on the adopted cosmology used to convert observed redshift to comoving distance, the r ( z ) relation, as it changes the line elements along and across the line of sight differently.
Fuyu Dong +6 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source