Results 91 to 100 of about 179,347,395 (254)

The large-scale structure of the universe in one dimension

, 2004
I investigate statistical properties of one-dimensional fields in the universe such as the Lyα forest (Lyα absorptions in the quasar spectrum) and inverted line-of-sight densities.
Zhan, Hu
core   +4 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The DESI DR1 Peculiar Velocity Survey: Global Zero-point and H0 Constraints

The Astrophysical Journal
The Dark Energy Spectroscopic Instrument (DESI) in its first Data Release (DR1) already provides more than 100,000 galaxies with relative distance measurements.
A. Carr, C. Howlett, A. J. Amsellem, Tamara M. Davis, K. Said, D. Parkinson, A. Palmese, J. Aguilar, S. Ahlen, J. Bautista, S. BenZvi, D. Bianchi, C. Blake, D. Brooks, T. Claybaugh, A. Cuceu, A. de la Macorra, P. Doel, K. Douglass, S. Ferraro, J. E. Forero-Romero, E. Gaztañaga, S. Gontcho A Gontcho, G. Gutierrez, H. K. Herrera-Alcantar, K. Honscheid, D. Huterer, M. Ishak, R. Joyce, A. G. Kim, D. Kirkby, A. Kremin, O. Lahav, C. Lamman, M. Landriau, L. Le Guillou, M. E. Levi, M. Manera, A. Meisner, R. Miquel, J. Moustakas, S. Nadathur, W. J. Percival, F. Prada, I. Pérez-Ràfols, F. Qin, C. Ross, G. Rossi, E. Sanchez, D. Schlegel, H. Seo, D. Sprayberry, G. Tarlé, R. J. Turner, B. A. Weaver, P. Zarrouk, R. Zhou, H. Zou   +57 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Large-scale structure from quantum fluctuations in the early universe [PDF]

, 2000
A better understanding of the formation of large-scale structure in the Universe is arguably the most pressing question in cosmology. The most compelling and promising theoretical paradigm, Inflation + Cold Dark Matter, holds that the density ...
Turner, Michael
core  

Debiasing with Diffusion: Probabilistic Reconstruction of Dark Matter Fields from Galaxies with CAMELS

The Astrophysical Journal
Galaxies are biased tracers of the underlying cosmic web, which is dominated by dark matter (DM) components that cannot be directly observed. Galaxy formation simulations can be used to study the relationship between DM density fields and galaxy ...
Victoria Ono, Core Francisco Park, Nayantara Mudur, Yueying Ni, Carolina Cuesta-Lazaro, Francisco Villaescusa-Navarro   +5 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Imprints of Primordial Non-Gaussianity on Large Scale Structure in the Universe

, 2016
Philosophiae Doctor - PhDLarge scale structure in the universe is one of the most important probing tools for cosmological modelling. Assuming the hot big bang model of the universe, the expansion history has undergone two phases of acceleration.
Hashim, Mahmoud Yousif Ali Wahba
core   +1 more source

The SPT-deep Cluster Catalog: Sunyaev–Zel’dovich Selected Clusters from Combined SPT-3G and SPTpol Measurements over 100 Square Degrees

The Astrophysical Journal
We present a catalog of 500 galaxy cluster candidates in the SPT-Deep field: a 100 deg ^2 field that combines data from the SPT-3G and SPTpol surveys to reach noise levels of 3.0, 2.2, and 9.0 μ K-arcmin at 95, 150, and 220 GHz, respectively.
K. Kornoelje, L. E. Bleem, E. S. Rykoff, T. M. C. Abbott, P. A. R. Ade, M. Aguena, O. Alves, A. J. Anderson, F. Andrade-Oliveira, B. Ansarinejad, M. Archipley, M. L. N. Ashby, J. E. Austermann, D. Bacon, L. Balkenhol, Matthew B. Bayliss, J. A. Beall, K. Benabed, A. N. Bender, B. A. Benson, F. Bianchini, S. Bocquet, F. R. Bouchet, D. Brooks, D. L. Burke, M. Calzadilla, M. G. Campitiello, E. Camphuis, J. E. Carlstrom, A. Carnero Rosell, J. Carretero, C. L. Chang, P. Chaubal, H. C. Chiang, P. M. Chichura, A. Chokshi, T.-L. Chou, R. Citron, A. Coerver, C. Corbett Moran, M. Costanzi, T. M. Crawford, A. T. Crites, L. N. da Costa, C. Daley, T. de Haan, J. De Vicente, S. Desai, K. R. Dibert, M. A. Dobbs, P. Doel, M. Doohan, A. Doussot, D. Dutcher, W. Everett, S. Everett, C. Feng, K. R. Ferguson, J. Mena-Fern’andez, I. Ferrero, K. Fichman, B. Flaugher, B. Floyd, A. Foster, D. Friedel, J. Frieman, S. Galli, J. Gallicchio, A. E. Gambrel, J. García-Bellido, R. W. Gardner, R. Gassis, M. Gatti, F. Ge, E. M. George, G. Giannini, N. Goeckner-Wald, S. Grandis, D. Gruen, R. A. Gruendl, R. Gualtieri, F. Guidi, S. Guns, N. Gupta, G. Gutierrez, N. W. Halverson, S. R. Hinton, E. Hivon, G. P. Holder, D. L. Hollowood, W. L. Holzapfel, K. Honscheid, J. C. Hood, J. D. Hrubes, A. Hryciuk, N. Huang, J. Hubmayr, K. D. Irwin, D. J. James, F. Kéruzoré, A. R. Khalife, M. Klein, L. Knox, M. Korman, K. Kuehn, C.-L. Kuo, O. Lahav, A. T. Lee, S. Lee, K. Levy, D. Li, M. Lima, A. E. Lowitz, A. Lowitz, C. Lu, Guillaume Mahler, A. Maniyar, J. L. Marshal, J. L. Marshall, E. S. Martsen, M. McDonald, J. J. McMahon, F. Menanteau, M. Millea, R. Miquel, J. J. Mohr, J. Montgomery, J. Myles, Y. Nakato, T. Natoli, J. P. Nibarger, G. I. Noble, V. Novosad, R. L. C. Ogando, Y. Omori, A. Ouellette, S. Padin, Z. Pan, S. Patil, M. E. S. Pereira, K. A. Phadke, A. Pieres, A. A. Plazas Malag’on, A. W. Pollak, K. Prabhu, C. Pryke, W. Quan, M. Rahimi, A. Rahlin, C. L. Reichardt, M. Rodr’iguez-Monroy, A. K. Romer, M. Rouble, J. E. Ruhl, B. R. Saliwanchik, L. Salvati, S. Samuroff, E. Sanchez, Arnab Sarkar, A. Saro, K. K. Schaffer, E. Schiappucci, T. Schrabback, I. Sevilla-Noarbe, C. Sievers, G. Smecher, M. Smith, J. A. Sobrin, T. Somboonpanyakul, B. Stalder, A. A. Stark, V. Strazzullo, E. Suchyta, M. E. C. Swanson, C. Tandoi, G. Tarle, B. Thorne, C. To, C. Trendafilova, C. Tucker, C. Umilta, T. Veach, J. D. Vieira, M. Vincenzi, A. Vitrier, Y. Wan, G. Wang, N. Weaverdyck, J. Weller, N. Whitehorn, P. Wiseman, W. L. K. Wu, V. Yefremenko, M. R. Young, J. A. Zebrowski, Y. Zhang   +195 more
doaj   +1 more source