Results 71 to 80 of about 11,465 (256)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Large Scale Structure in the Universe [PDF]

Large Scale Structure in the Universe, 1995
Jan P. Mücket, Stefan Gottlöber, Volker Müller   +2 more
openaire   +2 more sources

The large scale structure of the universe

Nuclear Physics B, 1985
Abstract Observational data on galaxies and clusters of galaxies are reviewed in the context of how they relate to the large scale structure of the Universe. Various methods of interpreting these data are discussed.
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Parameter-masked Mock Data Challenge for Beyond-two-point Galaxy Clustering Statistics

The Astrophysical Journal
The past few years have seen the emergence of a wide array of novel techniques for analyzing high-precision data from upcoming galaxy surveys, which aim to extend the statistical analysis of galaxy clustering data beyond the linear regime and the ...
The Beyond-2pt Collaboration, Elisabeth Krause, Yosuke Kobayashi, Andrés N. Salcedo, Mikhail M. Ivanov, Tom Abel, Kazuyuki Akitsu, Raul E. Angulo, Giovanni Cabass, Sofia Contarini, Carolina Cuesta-Lazaro, ChangHoon Hahn, Nico Hamaus, Donghui Jeong, Chirag Modi, Nhat-Minh Nguyen, Takahiro Nishimichi, Enrique Paillas, Marcos Pellejero Ibañez, Oliver H. E. Philcox, Alice Pisani, Fabian Schmidt, Satoshi Tanaka, Giovanni Verza, Sihan Yuan, Matteo Zennaro   +25 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Galaxy Spin Alignment with Tidal Fields in the SDSS-IV MaNGA Survey

The Astrophysical Journal Letters
The tidal torque theory (TTT) predicts that galaxy spins are correlated with the surrounding tidal field, reflecting how angular momentum is acquired during structure formation.
Jun-Sung Moon, Teppei Okumura
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The DESI DR1 Peculiar Velocity Survey: Global Zero-point and H0 Constraints

The Astrophysical Journal
The Dark Energy Spectroscopic Instrument (DESI) in its first Data Release (DR1) already provides more than 100,000 galaxies with relative distance measurements.
A. Carr, C. Howlett, A. J. Amsellem, Tamara M. Davis, K. Said, D. Parkinson, A. Palmese, J. Aguilar, S. Ahlen, J. Bautista, S. BenZvi, D. Bianchi, C. Blake, D. Brooks, T. Claybaugh, A. Cuceu, A. de la Macorra, P. Doel, K. Douglass, S. Ferraro, J. E. Forero-Romero, E. Gaztañaga, S. Gontcho A Gontcho, G. Gutierrez, H. K. Herrera-Alcantar, K. Honscheid, D. Huterer, M. Ishak, R. Joyce, A. G. Kim, D. Kirkby, A. Kremin, O. Lahav, C. Lamman, M. Landriau, L. Le Guillou, M. E. Levi, M. Manera, A. Meisner, R. Miquel, J. Moustakas, S. Nadathur, W. J. Percival, F. Prada, I. Pérez-Ràfols, F. Qin, C. Ross, G. Rossi, E. Sanchez, D. Schlegel, H. Seo, D. Sprayberry, G. Tarlé, R. J. Turner, B. A. Weaver, P. Zarrouk, R. Zhou, H. Zou   +57 more
doaj   +1 more source