Results 71 to 80 of about 19,799 (306)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The Arrow of Time in Cosmology [PDF]
, 2002 Scientific cosmology is an empirical discipline whose objects of study are the large-scale properties of the universe. In this context, it is usual to call the direction of the expansion of the universe the "cosmological arrow of time". However, there is
Castagnino, Mario +2 more
core
Imprints of Primordial Non-Gaussianity on Large Scale Structure in the Universe [PDF]
, 2016 Philosophiae Doctor - PhDLarge scale structure in the universe is one of the most important probing tools for cosmological modelling. Assuming the hot big bang model of the universe, the expansion history has undergone two phases of acceleration.
Hashim, Mahmoud Yousif Ali Wahba
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Inflationary Imprints on the Large Scale Structure of the Universe
, 2022 Inflation is the predominant model describing the early universe, however we do not know much about the underlying theory, besides, there are other open questions in cosmology, for example about the nature of dark matter and dark energy.
Tranquilli, Nicola
core
Evolution of Multifractal Structure in the Large-scale Structure in the Universe [PDF]
, 2014 We have analyzed the evolution of multifractal structure in the Universe. The galaxies construct large-scale structure in the Universe. According to recent observations, the large-scale structure have multifractal structure during several h−1Mpc.
立川, 崇之
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Large Scale Structure Of The Universe
, 2007 How is the universe organized on large scales? How did this structure evolve from the unknown initial conditions of a rather smooth early universe to the present time? The answers to these questions will shed light on the cosmology we live in, the amount,
Neta Bahcall
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source