Results 101 to 110 of about 179,347,395 (254)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Learning the Universe with Cosmological Rescaling of Merger Trees and Semianalytic Galaxy Formation Models

The Astrophysical Journal
Learning cosmology from galaxy surveys requires large suites of simulations spanning the cosmological and astrophysical parameter space, yet hydrodynamical simulations of galaxy formation remain prohibitively expensive.
Richard Stiskalek, Lucia A. Perez, Shy Genel, Rachel S. Somerville, Raul E. Angulo, Sergio Contreras   +5 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Cosmic Tidal Reconstruction in Redshift Space

The Astrophysical Journal
Gravitational coupling between large- and small-scale density perturbations leads to anisotropic distortions to local small-scale matter fluctuations. Such local anisotropic distortions can be used to reconstruct large-scale matter distribution, known as
Shi-Hui Zang, Hong-Ming Zhu, Marcel Schmittfull, Ue-Li Pen   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Development of large-scale structure in the Universe

, 1991
This volume grew out of the 1988 Fermi lectures given by Professor Ostriker, and is concerned with cosmological models that take into account the large scale structure of the universe. He starts with homogeneous isotropic models of the universe and then,
Ostriker, J P
core  

Shock waves in the large-scale structure of the Universe

, 2015
Cosmological shock waves are induced during hierarchical formation of large-scale structure in the universe. Like most astrophysical shocks, they are collisionless, since they form in the tenuous intergalactic medium through electromagnetic viscosities ...
Kang, Hyesung, Ryu, Dongsu
core   +1 more source

Halo Asymmetry in the Modeling of Galaxy Clustering

The Astrophysical Journal
Conventional studies of galaxy clustering within the framework of halo models typically assume that the density profile of all dark matter halos can be approximated by the Navarro–Frenk–White (NFW) spherically symmetric profile.
Anna Durkalec, Agnieszka Pollo, Ummi Abbas   +2 more
doaj   +1 more source