Results 111 to 120 of about 442,368 (316)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Accurate N-body simulations with local primordial non-Gaussianities: Initial conditions and aliasing

Astronomy & Astrophysics
The new generation of galaxy surveys designed to constrain local primordial non-Gaussianity (PNG) requires N-body simulations that accurately reproduce its effects.
Adame Adrian Gutierrez, Avila Santiago, Gonzalez-Perez Violeta, Hahn Oliver, Yepes Gustavo, Manera Marc   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Exploring the Signature of Assembly Bias and Modified Gravity Using Small-scale Clusterings of Galaxies

The Astrophysical Journal
We apply a halo velocity bias model, γ _f , within the Aemulus simulation suite for General Relativity to investigate its efficacy in identifying the signature of assembly bias and Modified Gravity (MG).
Yirong Wang, Zhongxu Zhai, Xiaohu Yang, Jeremy L. Tinker   +3 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Tracing the high-z cosmic web with Quaia: Catalogues of voids and clusters in the quasar distribution

Astronomy & Astrophysics
Context. Understanding the formation and evolution of the cosmic web of galaxies is a fundamental goal of both theoretical and observational cosmology, which use various tracers of the cosmic large-scale structure at an ever wider range of redshifts ...
Arsenov N., Kovács A., Pérez Sar M., Bogdán Á. Sz., Sinigaglia F., Kitaura F. S., Favole G., Slavcheva-Mihova L.   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Lagrangian Perturbation Theory for Biased Tracers: Significance of the Number Conservation

The Astrophysical Journal
The Lagrangian perturbation theory provides a simple yet powerful way of computing the nonlinear matter power spectrum, and it has been applied to biased tracers such as halos and galaxies.
Peter Espenshade, Jaiyul Yoo
doaj   +1 more source

Large-scale galaxy correlations from the DESI first data release

Astronomy & Astrophysics
We quantify galaxy correlations using two distinct three-dimensional samples from the first data release of the Dark Energy Spectroscopic Instrument (DESI): the Bright Galaxy Sample (BGS) and the Luminous Red Galaxy Sample (LRGS).
Sylos Labini Francesco, Antal Tibor
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source