Results 91 to 100 of about 166,709,059 (292)

Large-scale structure from quantum fluctuations in the early universe [PDF]

, 2000
A better understanding of the formation of large-scale structure in the Universe is arguably the most pressing question in cosmology. The most compelling and promising theoretical paradigm, Inflation + Cold Dark Matter, holds that the density ...
Turner, Michael
core  

Intrinsic alignments in the FLAMINGO simulations with two-point statistics

Astronomy & Astrophysics
Intrinsic alignments are a major astrophysical contaminant for next generation large-sky surveys such as Euclid and LSST. Large hydrodynamic simulations are crucial for informing the alignment modelling for these surveys.
Herle A., Chisari N. E., Hoekstra H., Navarro-Gironés D., Schaller M., Schaye J.   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The large-scale Structure and dynamics of the local universe [PDF]

, 2007
This thesis investigates the dynamics of the local Universe with particular reference to discovering the source of the Local Group (LG) motion. A redshift survey of the Great Attractor (GA) region, thought responsible for a significant fraction of the LG
Radburn-Smith, David James
core  

Emulating galaxy and peculiar velocity clustering on non-linear scales

Astronomy & Astrophysics
We explore the potential of cross-correlating galaxies and peculiar velocities on non-linear scales to enhance cosmological constraints. Leveraging the ABACUSSUMMIT simulation suite and the halo occupation distribution (HOD) formalism, we trained ...
Dumerchat T., Bautista J., Ravoux C., Aguilar J., Ahlen S., BenZvi S., Bianchi D., Brooks D., Claybaugh T., de la Macorra A., Doel P., Ferraro S., Forero-Romero J. E., Gaztañaga E., Gontcho A Gontcho S., Gutierrez G., Hahn C., Howlett C., Ishak M., Joyce R., Kirkby D., Kremin A., Lamman C., Landriau M., Le Guillou L., Manera M., Miquel R., Nadathur S., Percival W. J., Prada F., Pérez-Ràfols I., Rossi G., Sanchez E., Schlegel D., Schubnell M., Silber J., Sprayberry D., Tarlé G., Weaver B. A., Zou H.   +39 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Testing Inflation with Large Scale Structure: Connecting Hopes with Reality

, 2014
The statistics of primordial curvature fluctuations are our window into the period of inflation, where these fluctuations were generated. To date, the cosmic microwave background has been the dominant source of information about these perturbations ...
Anže Slosar, Valentin Assassi, Roland de Putter, Zhiqi Huang, Amir Hajian, Donghui Jeong, Dragan Huterer, Matias Zaldarriaga, Alexander van Engelen, P. Daniel Meerburg, Kendrick Smith, Marilena Loverde, Eva Silverstein, Neal Dalal, Sarah Shandera, J. Richard Bond, Daniel Green, George Stein, Olivier Doré, Matthew C. Johnson, Tobias Baldauf, Chris Hirata, Jonathan Braden, Elisabeth Krause, Marcelo Alvarez, Joel Meyers, Leonardo Senatore, Takeshi Kobayashi   +27 more
core   +1 more source

Large-scale structure of the early universe

The large-scale structure of the universe is one of the most active areas of research in modern astronomy. However, until recently our knowledge of the distribution of matter on large scales has been primarily limited to two epochs - the present epoch ...
Graham, Matthew James
core   +6 more sources

Galaxy Spin Transition Driven by the Misalignments between the Protogalaxy Inertia and Initial Tidal Tensors

The Astrophysical Journal
A numerical detection of the τ -driven transition of galaxy spins is presented, where τ is the degree of misalignment between the initial tidal field and protogalaxy inertia tensors.
Jun-Sung Moon, Jounghun Lee
doaj   +1 more source

A novel test of gravity: Does spacetime geometry track matter density?

Astronomy & Astrophysics
We propose a novel test of gravity that combines galaxy clustering with gravitational lensing. One of the cornerstone of general relativity is to link spacetime distortions to matter distribution through Einstein’s equations.
Bonvin Camille, Grimm Nastassia, Tutusaus Isaac   +2 more
doaj   +1 more source