Results 91 to 100 of about 442,368 (316)

More power on large scales

Astronomy & Astrophysics
The high value of the cosmic microwave dipole may be telling us that dark matter is macroscopic rather than a fundamental particle. The possible presence of a significant dark matter component in the form of primordial black holes (PBHs) suggests that ...
Mould Jeremy
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

From redshift to real space: Combining linear theory with neural networks

Astronomy & Astrophysics
Context. Spectroscopic redshift surveys are key to tracing the large-scale structure (LSS) of the Universe and testing the Λ Cold Dark Matter model. However, redshifts as distance proxies introduce distortions in the 3D galaxy distribution.
Maragliano Edoardo, Ganeshaiah Veena Punyakoti, Degni Giulia, Franco Branchini Enzo   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Mapping the Large-Scale Structure of the Universe

Science, 2005
In a large scale view of the universe, galaxies are the basic unit of structure. A typical bright galaxy may contain 100 billion stars and span tens of thousands of light years, but the empty expanses between the galaxies are much larger still. Galaxies are not randomly distributed in space, but instead reside in groups and clusters, which are ...
openaire   +2 more sources

The Large Scale Structure of The X-Ray Universe [PDF]

Symposium - International Astronomical Union, 1988
The clustering of the background-contributing X-ray sources is reflected in the excess (i.e., non-Poisson) fluctuations in the X-ray background (XRB). Observational limits on ΔI/I can therefore be used to constrain either the clumpiness of X-ray sources or their contribution to the XRB if their clustering properties are known (see Barcons & Fabian ...
X. Barcons, A.C. Fabian
openaire   +1 more source

Extending the scope of models for large-scale structure formation in the Universe [PDF]

, 1999
We propose a phenomenological generalization of the models of large-scale structure formation in the Universe by gravitational instability in two ways: we include pressure forces to model multi-streaming, and noise to model fluctuations due to neglected ...
Buchert, Thomas, Dominguez, Alvaro, Perez-Mercader, Juan   +2 more
core   +1 more source

X-ray sources as tracers of the large-scale structure in the Universe

, 2000
We review the current status of studies of large-scale structure in the X-ray Universe. After motivating the use X-rays for cosmological purposes, we discuss the various approaches used on different angular scales including X-ray background multipoles ...
Barcons, X., Carrera, F. J., Ceballos, M. T., Mateos, S.   +3 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source