Results 71 to 80 of about 11,581 (259)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Testing the cosmological principle with quasars

Astronomy & Astrophysics
The cosmological principle posits that the universe is homogeneous and isotropic on the large scales. In history, the cosmological principle was confirmed by various cosmological observations from CMB to large scale structure.
Chen Shuangnan, Yang Xiaofeng, Ren Yunliang, Zhang Xuwei, Shi Yangjun, Cheng Cheng, He Xiaolong, Guo Sufen   +7 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Large Scale Structure in the Universe [PDF]

Large Scale Structure in the Universe, 1995
Jan P. Mücket, Stefan Gottlöber, Volker Müller   +2 more
openaire   +2 more sources

Lagrangian Perturbation Theory for Biased Tracers: Significance of the Number Conservation

The Astrophysical Journal
The Lagrangian perturbation theory provides a simple yet powerful way of computing the nonlinear matter power spectrum, and it has been applied to biased tracers such as halos and galaxies.
Peter Espenshade, Jaiyul Yoo
doaj   +1 more source

Simulated rotation measure sky from primordial magnetic fields

Astronomy & Astrophysics
Primordial magnetic fields (PMFs) – magnetic fields that originate in the early Universe and permeate the cosmological scales today – can explain the observed micro-gauss-level magnetisation of galaxies and their clusters.
Mtchedlidze S., Vazza F., Du X., Carretti E., Stuardi C., O’Sullivan S. P.   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Kullback–Leibler Divergence and the Convergence Rate of Fast Covariance Matrix Estimators in Galaxy Clustering Analysis

The Astrophysical Journal
We present a method to quantify the convergence rate of the fast estimators of the covariance matrices in the large-scale structure analysis. Our method is based on the Kullback–Leibler (KL) divergence, which describes the relative entropy of two ...
Zhigang Li, Zhejie Ding, Yu Yu, Pengjie Zhang   +3 more
doaj   +1 more source

STATISTICAL ANALYSIS OF LARGE-SCALE STRUCTURE OF UNIVERSE

Odessa Astronomical Publications, 2017
While galaxy cluster catalogs were compiled many decades ago, other structural elements of cosmic web are detected at definite level only in the newest works. For example, extragalactic filaments were described by velocity field and SDSS galaxy distribution
A. V. Tugay
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source