Results 81 to 90 of about 11,581 (259)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large-scale galaxy correlations from the DESI first data release

Astronomy & Astrophysics
We quantify galaxy correlations using two distinct three-dimensional samples from the first data release of the Dark Energy Spectroscopic Instrument (DESI): the Bright Galaxy Sample (BGS) and the Luminous Red Galaxy Sample (LRGS).
Sylos Labini Francesco, Antal Tibor
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The shape of pancakes: Catastrophe theory and Gaussian statistics in 2D

Astronomy & Astrophysics
Cold dark matter (CDM) can be thought of as a 2D (or 3D) sheet of particles in 4D (or 6D) phase-space because its velocity dispersion is negligible.
Parichha Abineet, Colombi Stephane, Saga Shohei, Taruya Atsushi   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Beyond power spectrum to unveil systematics on HI intensity maps

Astronomy & Astrophysics
Context. H I intensity mapping is a promising technique to probe large-scale structure, traditionally analyzed via two-point statistics such as the angular power spectrum.
Gorbatchev Pauline, Starck Jean-Luc, Camera Stefano, Spinelli Marta   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

ELG×LRG Distribution through Dark Matter Halo Dynamics

The Astrophysical Journal
We investigate the clustering and halo occupation distribution (HOD) of DESI Y1 emission-line (ELGs) and luminous red (LRGs) galaxies at 0.8 
Ginevra Favole, Francisco-Shu Kitaura, Boryana Hadzhiyska, Daniel Eisenstein, Lehman H. Garrison, Sownak Bose   +5 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

General Relativity and the Bulk-flow Puzzle

The Astrophysical Journal
Bulk peculiar flows are commonplace in the Universe, with many surveys reporting their presence on scales spanning between few hundred and several hundred Mpc.
Christos G. Tsagas
doaj   +1 more source