Results 61 to 70 of about 11,581 (259)

The large scale structure of the universe

Nuclear Physics B, 1985
Abstract Observational data on galaxies and clusters of galaxies are reviewed in the context of how they relate to the large scale structure of the Universe. Various methods of interpreting these data are discussed.
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Large-scale structure in the Universe [PDF]

Monthly Notices of the Royal Astronomical Society, 1985
On etudie des modeles contenant les caracteristiques essentielles de la theorie adiabatique de la formation des ...
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Accurate N-body simulations with local primordial non-Gaussianities: Initial conditions and aliasing

Astronomy & Astrophysics
The new generation of galaxy surveys designed to constrain local primordial non-Gaussianity (PNG) requires N-body simulations that accurately reproduce its effects.
Adame Adrian Gutierrez, Avila Santiago, Gonzalez-Perez Violeta, Hahn Oliver, Yepes Gustavo, Manera Marc   +5 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Exploring the Signature of Assembly Bias and Modified Gravity Using Small-scale Clusterings of Galaxies

The Astrophysical Journal
We apply a halo velocity bias model, γ _f , within the Aemulus simulation suite for General Relativity to investigate its efficacy in identifying the signature of assembly bias and Modified Gravity (MG).
Yirong Wang, Zhongxu Zhai, Xiaohu Yang, Jeremy L. Tinker   +3 more
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Tracing the high-z cosmic web with Quaia: Catalogues of voids and clusters in the quasar distribution

Astronomy & Astrophysics
Context. Understanding the formation and evolution of the cosmic web of galaxies is a fundamental goal of both theoretical and observational cosmology, which use various tracers of the cosmic large-scale structure at an ever wider range of redshifts ...
Arsenov N., Kovács A., Pérez Sar M., Bogdán Á. Sz., Sinigaglia F., Kitaura F. S., Favole G., Slavcheva-Mihova L.   +7 more
doaj   +1 more source