Results 91 to 100 of about 84,841 (279)

Liver resections: complications and survival outcome [PDF]

, 2007
none1noToday, liver resection represents one of the most effective therapies in the treatment of defined liver diseases, particularly for hepatocellular carcinomas, liver metastases and tumors originating from the bile ducts.
Grazi, Gian Luca
core   +1 more source

Molecular–clinical characteristics and treatment outcomes in 163 metastatic colorectal neuroendocrine carcinomas with a comparison to colorectal adenocarcinomas

International Journal of Cancer, EarlyView.
What's New? Colorectal neuroendocrine carcinoma (CR‐NEC) is a rare digestive neuroendocrine neoplasm that frequently exhibits an adenocarcinoma component. Nonetheless, the underlying biology of CR‐NEC remains poorly understood. This study examined molecular and clinical features and palliative chemotherapy outcomes of metastatic CR‐NEC, with comparison
Siren Morken, Seppo W. Langer, Geir Olav Hjortland, Anna Sundlöv, Eva Hofsli, Morten Ladekarl, Elizaveta Tabaksblat, Lene Weber Vestermark, Johanna Svensson, Ulrich Knigge, Luís Nunes, Bengt Glimelius, Per Pfeiffer, Kristine Aasebø, Jörg Assmus, Erik Vassella, Inger Marie Bowitz Lothe, Anne Couvelard, Aurel Perren, Stian Knappskog, Halfdan Sorbye   +20 more
wiley   +1 more source

Tarlatamab for Large Cell Neuroendocrine Carcinoma in a Young Adult: A Case Report

JTO Clinical and Research Reports
A 20-year-old man with metastatic large cell neuroendocrine carcinoma of the lung was treated with the delta-like ligand 3–targeting bispecific T cell engager, tarlatamab. Treatment was complicated by transient cytokine release syndrome but resulted in a
Shetal A. Patel, MD, PhD, Young Whang, MD, PhD, Chaely Medley, NP, Kevin Chen, PharmD, Jasmine Jordan, BS, Dante Bortone, PhD, Benjamin Vincent, MD, PhD, Jared Weiss, MD   +7 more
doaj   +1 more source

External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder?

Case Reports in Oncological Medicine, 2017
Neuroendocrine tumors commonly involve the respiratory and gastrointestinal systems. Primary genitourinary neuroendocrine tumors are rare, accounting for less than 1% of all bladder carcinomas. Four histopathologic subtypes have been described.
Ali Zakaria, Bayan Al Share, Sri Kollepara, Cynthia Vakhariya   +3 more
doaj   +1 more source

Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. [PDF]

, 2013
Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (Gli1 ...
Bermudez, Olga, Eickelberg, Oliver, Hennen, Elisabeth, Koch, Ina, Lindner, Michael   +4 more
core   +3 more sources

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Pancreatic tumors imaging: an update [PDF]

, 2016
Currently, ultrasound (US), computed tomography (CT) and Magnetic Resonance imaging (MRI) represent the mainstay in the evaluation of pancreatic solid and cystic tumors affecting pancreas in 80-85% and 10-15% of the cases respectively. Integration of US,
Baccari, Paolo, Cappabianca, Salvatore, D'Andrea, Alfredo, Falcone, Giuseppe, Gravante, Sabrina, Manganaro, Lucia, Palumbo, Barbara, Reginelli, Alfonso, Scialpi, Michele   +8 more
core   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Pulmonary Large Cell Neuroendocrine Carcinoma

Haigan, 2006
1999年にWHOの肺癌組織分類が改定され，大細胞癌がより詳細に分類された．これは単に組織型が細分化されただけでなく，肺癌の予後を組織型から推測するという観点からみても非常に大きな意味をもつものであった．特に肺大細胞神経内分泌癌（large cell neuroendocrine carcinoma，以下LCNEC）は実際には稀な腫瘍ではなく，認識の広がりに伴って診断される機会が多くなっている．1991年のTravisらの報告以降，LCNECは，aggressive behaviorを有しており，予後不良な症例が多いという認識はほぼ大勢となりつつある．分類上は大細胞癌の一亜型として分類されてはいるが，生物学的特徴は小細胞癌と類似した特徴を有しており，high-grade neuroendocrine
Akira Iyoda, Kenzo Hiroshima, Yukio Nakatani, Takehiko Fujisawa   +3 more
openaire   +2 more sources

Early symptoms and sensations as predictors of lung cancer: a machine learning multivariate model. [PDF]

, 2019
The aim of this study was to identify a combination of early predictive symptoms/sensations attributable to primary lung cancer (LC). An interactive e-questionnaire comprised of pre-diagnostic descriptors of first symptoms/sensations was administered to ...
Bernhardson, B-M., Eriksson, L. E., Forshed, J., Henriksson, R., Kölbeck, K., Lehtiö, J., Levitsky, A., Olin, M., Pernemalm, M., Tishelman, C.   +9 more
core   +1 more source