Results 141 to 150 of about 84,841 (279)

Novel therapeutic strategy targeting STMN1 using chlorambucil‐conjugated pyrrole–imidazole polyamide in small cell lung cancer

International Journal of Cancer, Volume 158, Issue 5, Page 1336-1347, 1 March 2026.
What's New? Small cell lung cancer (SCLC) is aggressive and difficult to treat but exhibits high levels of stathmin 1 (STMN1), a candidate therapeutic target. In this study, the authors synthesized a chlorambucil (Chb)‐conjugated pyrrole–imidazole polyamide (PIP) compound targeting the STMN1 promoter and DNA sequences and evaluated its efficacy in ...
Ryohei Yoshikawa, Takayoshi Watanabe, Yoichi Ohtaki, Toshikazu Bando, Hiroshi Sugiyama, Takuya Araki, Hideaki Yashima, Bilguun Erkhem‐Ochir, Haruka Okami, Gendensuren Dorjkhorloo, Ikuma Shioi, Toshiteru Nagashima, Natsuko Kawatani, Tomohiro Yazawa, Eiji Narusawa, Takayuki Kosaka, Osamu Kawashima, Mitsuhiro Kamiyoshihara, John D. Minna, Luc Girard, Ken Shirabe, Hiroki Nagase, Kimihiro Shimizu, Takehiko Yokobori   +23 more
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The changing face of hepatic resection [PDF]

, 1989
Iwatsuki, S, Sheahan, DG, Starzl, TE
core   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Cancer Comorbidities: Clinical Impacts, Mechanistic Insights, and Management Strategies

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review focuses on cancer comorbidities, examining their clinical impacts and mechanistic insights. It further examines key management challenges, including evidence gaps, the lack of precise assessment tools, limited management frameworks, and underdeveloped multidisciplinary collaborations.
Taoxing Peng, Siyi Chen, Xin He, Yuxin Yang, Yuexiang Ren, Yuxuan Sun, Fuli Shi, Yangfeng Lv, Xiangqiong Wen, Yujian Wen, Peng Yu, Weizhu Liu, Qiongfeng Chen, Xianhe Yang, Shan Xu, Jianming Li   +15 more
wiley   +1 more source

Identification of BCL2L11 as a Candidate Gene for Hereditary Predisposition to Non‐Medullary Thyroid Cancer Using Familial Whole‐Exome‐Sequencing

Clinical Genetics, Volume 109, Issue 3, Page 458-469, March 2026.
Whole‐exome sequencing of five families with non‐medullary thyroid cancer revealed three candidate genes. Functional analyses confirmed BCL2L11 as a strong candidate gene for hereditary predisposition to non‐medullary thyroid cancer. ABSTRACT Familial non‐medullary thyroid cancer, defined as two or more affected first‐degree relatives, accounts for 3 ...
Duygu Abbasoglu, Mathis Lepage, Nicolas Sonnier, Sandrine Viala, Nancy Uhrhammer, Flora Ponelle‐Chachuat, Anne Cayre, Maud Privat, Mathias Cavaillé, Yannick Bidet   +9 more
wiley   +1 more source

Acoustic Sensing as a Tool for Brain Tumor Diagnostics

Advanced Sensor Research, Volume 5, Issue 2, February 2026.
Surface acoustic wave (SAW) sensing is used to distinguish non‐neoplastic brain tissue from primary and metastatic tumors based on their acoustic attenuation signatures. Ex vivo human brain samples reveal clear tissue‐specific mechanical profiles, correlating with stiffness and malignancy.
Melanie E. M. Stamp, Friederike Liesche‐Starnecker, Tina Schaller, Peter Baumgarten, Nadine Lilla, Dorothee Mielke, David Collins   +6 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation

Autopsy and Case Reports, 2018
High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare.
Lucinda Calheiros Guimarães, Priscila Leandro Garcia, João Badaró Castro Filho, Antonio Carlos Oliveira Meneses   +3 more
doaj