Results 141 to 150 of about 209,931 (313)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Grand Design Spiral Arms in the Compact, Embedded Protoplanetary Disk of Haro 6-13

The Astrophysical Journal
Millimeter continuum spiral arms have so far only been detected in a handful of protoplanetary disks, and thus we have a limited understanding of the circumstances in which they can form.
Jane Huang, Masataka Aizawa, Jaehan Bae, Sean M. Andrews, Myriam Benisty, Edwin A. Bergin, Stefano Facchini, Christian Ginski, Michael Küffmeier   +8 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Disentangling Target Lines from Interlopers and Continuum with Neural Networks: A SPHEREx Intensity Mapping Case Study

The Astrophysical Journal
Line-intensity mapping (LIM) traces the large-scale distribution of matter by measuring fluctuations in aggregate line emission from unresolved galaxies and the intergalactic medium, providing a powerful probe of both astrophysics and cosmology. However,
Marina S. Cagliari, Zucheng Gao, Azadeh Moradinezhad Dizgah   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

On a Problem of Proving the Existence of an Equilibrium in a Large Economy without Free Disposal: A problem of a purely finitely additive measure arising from the Fatou's lemma in several dimensions [PDF]

It is well-known in the literature that the free disposability or the desirability of all the commodities is needed to ensure the existence of an equilibrium in a large economy with a continuum of economic agents.
Yamazaki, Akira
core  

Power dissipation in an asymmetric superconducting resonator

New Journal of Physics
Resonator asymmetry is a common feature in superconducting resonators, often arising from parasitic effects or non-ideal bias conditions in the microwave system.
Albert Wandui, Bryan Steinbach, James Bock, Lorenzo Minutolo, Roger O’Brient   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source