Results 41 to 50 of about 217,046 (269)
BuildingsThis study studies the deformation characteristics of the diversion tunnel of Jinping II Hydropower Station in order to guarantee the safety of the excavation of a large-section soft rock tunnel with a depth of 1000 m and increased ground stress.
Zhen Yang +4 more
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Yantu gongcheng xuebao, 2023 The sloping ground may suffer from lateral spreading due to earthquake-induced soil softening or liquefaction, and this deformation is usually relatively limited in the gentle sloping ground.
LI Yunyi , WANG Rui , ZHANG Jianmin
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Acta Mechanica Sinica, 2020 AbstractThe theory of plasticity as a special field of continuum mechanics deals with the irreversible, i.e. permanent, deformation of solids. Under the action of given loads or deformations, the state of the stresses and strains or the strain rates in these bodies is described.
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Research Advances in Large Deformation Analysis and Applications of the Material Point Method
Applied SciencesLarge deformation analysis is a crucial foundation for studying the nonlinear behavior and progressive damage of materials and structures. Traditional mesh methods often struggle with large-scale mesh distortion when dealing with such issues, which can ...
Changhong Zhou +4 more
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Cosserat-particle finite element method for large deformation analysis of rock and soil
Yantu gongcheng xuebao, 2023 The particle finite element method (PFEM) inherits the solid mathematical foundation of the finite element method and possesses the capability of modeling the problems with large deformation and complex boundary, so it has been widely used in the fields ...
TANG Hongxiang 1, CUI Jiaming 2, ZHANG Xue 3, ZHANG Lei 1, LIU Letian 4
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