Results 61 to 70 of about 7,573,905 (257)

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

The large-scale surface uplift in the Altiplano-Puna region of Bolivia: A parametric study of source characteristics and crustal rheology using finite element analysis [PDF]

, 2013
This paper focuses on the driving mechanism behind a 70 km wide region of ground uplift centered on Uturuncu volcano, in the Altiplano-Puna region of southern Bolivia.
Hickey, James, Gottsmann, Joachim, del Potro, Rodrigo   +2 more
core   +1 more source

Characteristics and control techniques of soft rock tunnel lining cracks in high geo-stress environments: Case study of Wushaoling tunnel group

Open Geosciences
A high geo-stress environment severely damages tunnel structures owing to the large deformation of the surrounding rock, thereby threatening their safety.
Han Jianyong, Liu Dong, Zhang Shengze, Chen Yang, Zhang Yongzhong, Zhao Lijun, He Caishan, Zhao Mingcheng   +7 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

An adaptive local meshfree updated Lagrangian approach for large deformation analysis of metal forming [PDF]

, 2010
The large deformation analysis is one of major challenges in numerical modelling and simulation of metal forming. Because no mesh is used, the meshfree methods show good potential for the large deformation analysis.
Gu, YuanTong
core   +1 more source

Friction Analysis on Scratch Deformation Modes of Visco-Elastic-Plastic Materials [PDF]

, 2012
Understanding of abrasion resistance and associated surfaces deformation mechanisms is of primary importance in materials engineering and design. Instrumented scratch testing has proven to be a useful tool for characterizing the abrasion resistance of ...
D.J. , Schipper, J. , Jamari, I. , Syafaat, Budi , Setiyana   +3 more
core   +1 more source

Numerical simulation of complete instability process of shield tunnel excavation face based on SPH method

Yantu gongcheng xuebao
Given the limitations of traditional grid-based numerical methods in simulating large deformation problems of geotechnical materials, this paper applies a meshless numerical method—Smoothed Particle Hydrodynamics (SPH)—to a full process simulation of ...
MA Yangchen1 , WENG Xiaolin1, SUN Yufeng1 , YE Fei1, MA Yue2, WONG K K Henry3, PARDOEN Benoît3
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Estimation of Strain-Softening Parameters of Marine Clay Using the Initial T-Bar Penetration Test

Journal of Marine Science and Engineering
T-bar penetrometers have been widely used to measure strength parameters of marine clay in laboratory and in situ tests. However, using the deep resistance factor derived from full-flow conditions to evaluate the undrained shear strength of shallow clay ...
Qinglai Fan, Zhaoxia Lin, Mengmeng Sun, Yunrui Han, Ruiying Yin   +4 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source