Results 111 to 120 of about 8,481,699 (293)

The large deviation principle for the Erdős-Rényi random graph [PDF]

, 2011
What does an Erdős-Rényi graph look like when a rare event happens? This paper answers this question when p is fixed and n tends to infinity by establishing a large deviation principle under an appropriate topology.
Varadhan, S.R.S., Chatterjee, Sourav, S.R.S. Varadhan, Sourav Chatterjee   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Research on high-precision large-aperture laser differential confocal-interferometric optical element multi-parameter measurement method

Light: Advanced Manufacturing
To fulfill the requirements of high-precision common baseline measurement for multiple parameters, such as surface profiling and the curvature radius of large-aperture optical elements on the same instrument, this paper proposes a research on a high ...
Weiqian Zhao, Liang Tang, Shuai Yang, Lirong Qiu   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A large deviation principle for the reduction of product representations [PDF]

Proceedings of the American Mathematical Society, 1990
A large deviation principle is proved for a family of measures {
openaire   +2 more sources

The large deviation principle for the on-off Weibull sojourn process [PDF]

, 2008
This article proves that the on-off renewal process with Weibull sojourn times satisfies the large deviation principle on a nonlinear scale. Unusually, its rate function is not convex.
Duffy, K.R., Duffy, Ken R., Sapozhnikov, Artem, Sapozhnikov, A.   +3 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Generalized free energy and excess/housekeeping decomposition in nonequilibrium systems: From large deviations to thermodynamic speed limits

Physical Review Research
In genuine nonequilibrium systems under continuous driving, thermodynamic forces are nonconservative and cannot be described by any free energy potential.
Artemy Kolchinsky, Andreas Dechant, Kohei Yoshimura, Sosuke Ito   +3 more
doaj   +1 more source

Experimental Study of ABS Material Shrinkage and Deformation Based on Fused Deposition Modeling

MATEC Web of Conferences, 2016
The CAD model can be directly converted into physical model by rapid prototyping , which provides more convenient means for concurrent design in physical verification.
Xu Yaodong
doaj   +1 more source