Results 51 to 60 of about 7,295,044 (195)
Environmental Research: ClimateThe signal-to-noise ratio paradox is interpreted as the climate model’s ability to predict observations better than the model itself. This view is counterintuitive, given that climate models are simplified numerical representations of complex earth ...
Yanan Duan, Sanjiv Kumar
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FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
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Progress in Earth and Planetary Science, 2023 This paper presents the 1000 ensemble flood simulations using ensemble rainfalls simulated by 4D LETKF. The number of ensemble rainfall members is large as 1000 compared to the operational rainfall products of two-digit numbers to avoid sampling errors ...
Kenichiro Kobayashi +7 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Unprecedented daily winter extremes for the UK energy sector
Environmental Research CommunicationsAs the UK power system transitions towards a greater share of variable renewable energy resources, the system becomes more weather dependent. During winter, the most challenging conditions occur when low wind speeds are accompanied by cold temperatures ...
Benjamin W Hutchins +5 more
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Pacific Ocean Variability Influences the Time of Emergence of a Seasonally Ice‐Free Arctic Ocean
Geophysical Research Letters, 2019 The Arctic Ocean is projected to become seasonally ice‐free before midcentury unless greenhouse gas emissions are rapidly reduced, but exactly when this could occur depends considerably on internal climate variability.
J. A. Screen, C. Deser
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
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In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
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Bagging ensemble selection [PDF]
, 2011 Ensemble selection has recently appeared as a popular ensemble learning method, not only because its implementation is fairly straightforward, but also due to its excellent predictive performance on practical problems.
Quan Sun +3 more
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Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
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