Results 51 to 60 of about 85,058 (265)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Supergravities on branes

Journal of High Energy Physics, 2022
Supergravity brane solutions allow for a generalised type of Kaluza-Klein reduction onto brane worldvolumes. The known replacement of a flat worldvolume metric by a Ricci-flat metric constitutes a consistent Kaluza-Klein truncation of the starting higher-
Rahim Leung, K.S. Stelle
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Quasinormal ringing of de Sitter braneworlds

Journal of High Energy Physics
Compared with the Poincaré braneworld, the de Sitter (dS) braneworld aligns more closely with the present universe characterized by a small but finite cosmological constant.
Hai-Long Jia, Wen-Di Guo, Yu-Xiao Liu, Qin Tan   +3 more
doaj   +1 more source

Holographic self-tuning of the cosmological constant

Journal of High Energy Physics, 2017
We propose a brane-world setup based on gauge/gravity duality in which the four-dimensional cosmological constant is set to zero by a dynamical self-adjustment mechanism. The bulk contains Einstein gravity and a scalar field. We study holographic RG flow
Christos Charmousis, Elias Kiritsis, Francesco Nitti   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Localization of scalar field on the brane-world by coupling with gravity

Journal of High Energy Physics
In this paper, we consider a coupling mechanism between the kinetic term and the gravity, in which a coupling function F (R) is introduced into the kinetic term of the five-dimensional scalar field. Based on this scenario, we investigate the localization
Heng Guo, Yong-Tao Lu, Cai-Ling Wang, Yue Sun   +3 more
doaj   +1 more source

Tensor perturbations and thick branes in higher-dimensional f(R) gravity

Journal of High Energy Physics, 2020
We study brane worlds in an anisotropic higher-dimensional spacetime within the context of f(R) gravity. Firstly, we demonstrate that this spacetime with a concrete metric ansatz is stable against linear tensor perturbations under certain conditions ...
Zheng-Quan Cui, Zi-Chao Lin, Jun-Jie Wan, Yu-Xiao Liu, Li Zhao   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Black Hole Production and Large Extra Dimensions [PDF]

Physical Review Letters, 2002
Black hole (BH) production at colliders is possible when the colliding energy is above the Planck scale, which can effectively be at TeV scale in models of large extra dimensions. In this work, we study the production of black holes at colliders and discuss the possible signatures.
openaire   +3 more sources