Results 61 to 70 of about 1,056,281 (276)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Quasinormal modes and echoes of a double braneworld

Journal of High Energy Physics
In this work, we study the gravitational quasinormal modes and the gravitational echoes of a double braneworld. The double braneworld is a kind of split thick brane, which is crucial for addressing the hierarchy problem in the thick brane scenarios ...
Qin Tan, Sheng Long, Weike Deng, Jiliang Jing   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Bispectrum from five-dimensional inflation

Journal of High Energy Physics
It was proposed that five-dimensional (5D) inflation can blow up the size of a compact dimension from the 5D Planck length to the micron size, as required by the dark dimension proposal, relating the weakness of the actual gravitational force to the size
Ignatios Antoniadis, Auttakit Chatrabhuti, Jules Cunat, Hiroshi Isono   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Supergravities on branes

Journal of High Energy Physics, 2022
Supergravity brane solutions allow for a generalised type of Kaluza-Klein reduction onto brane worldvolumes. The known replacement of a flat worldvolume metric by a Ricci-flat metric constitutes a consistent Kaluza-Klein truncation of the starting higher-
Rahim Leung, K.S. Stelle
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Low-Scale Axion from Large Extra Dimensions [PDF]

, 2000
The mass of the axion and its decay rate are known to depend only on the scale of Peccei-Quinn symmetry breaking, which is constrained by astrophysics and cosmology to be between $10^9$ and $10^{12}$ GeV.
't Hooft, Adler, Adler, Alavi-Harat, Antoniadis, Arkani-Hamed, Arkani-Hamed, Arkani-Hamed, Arkani-Hamed, Bell, Callan, Chang, Christenson, Demir, Demir, Di Lella, Dienes, Dine, Ernest Ma, Harris, Jackiw, Kim, Ma, Ma, Martti Raidal, Nilles, Peccei, Raffelt, Rosenberg, Sakamura, Sakharov, Shifman, Utpal Sarkar, Weinberg, Wilczek, Zhitnitskii   +35 more
core   +3 more sources

Quasinormal ringing of de Sitter braneworlds

Journal of High Energy Physics
Compared with the Poincaré braneworld, the de Sitter (dS) braneworld aligns more closely with the present universe characterized by a small but finite cosmological constant.
Hai-Long Jia, Wen-Di Guo, Yu-Xiao Liu, Qin Tan   +3 more
doaj   +1 more source

Holographic self-tuning of the cosmological constant

Journal of High Energy Physics, 2017
We propose a brane-world setup based on gauge/gravity duality in which the four-dimensional cosmological constant is set to zero by a dynamical self-adjustment mechanism. The bulk contains Einstein gravity and a scalar field. We study holographic RG flow
Christos Charmousis, Elias Kiritsis, Francesco Nitti   +2 more
doaj   +1 more source