Results 71 to 80 of about 9,158,241 (298)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Non-trivial thick brane realisations with 3-forms
Journal of High Energy PhysicsWe explore the construction of four-dimensional thick branes supported by massless 3-forms in a five-dimensional bulk space. The required residual Poincaré symmetry on the brane is realised as a combination of the bulk symmetries and the internal gauge ...
Bruno J. Barros, Jose Beltrán Jiménez
doaj +1 more source
Holographic self-tuning of the cosmological constant
Journal of High Energy Physics, 2017 We propose a brane-world setup based on gauge/gravity duality in which the four-dimensional cosmological constant is set to zero by a dynamical self-adjustment mechanism. The bulk contains Einstein gravity and a scalar field. We study holographic RG flow
Christos Charmousis +2 more
doaj +1 more source
Journal of High Energy Physics, 2020 In this paper, we explore the possibility that a light dilaton can be the first sign of new physics at the LHC. The dilaton could emerge in approximate scale invariant UV completions of the SM as the Goldstone boson associated with the spontaneous ...
Aqeel Ahmed +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Gravitational echoes from braneworlds
Journal of High Energy PhysicsGravitational echoes can be used to probe the structure of spacetime. In this paper, we investigate the gravitational echoes in different braneworld models in five-dimensional spacetime. We derive the gravitational perturbation equations of these models,
Chun-Chun Zhu +3 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Searching for a dark dimension right-handed neutrino in KATRIN
Journal of High Energy PhysicsWe study the possibility that the Right-handed neutrino is a five-dimensional state propagating along a micron size extra dimension, as required in the dark dimension proposal.
Ignatios Antoniadis +2 more
doaj +1 more source
Gravitationally Induced Quantum Superposition Reduction With Large Extra Dimensions [PDF]
, 2006 A gravity-driven mechanism (``objective reduction\u27\u27) proposed to explain quantum state reduction is analyzed in light of the possible existence of large extra dimensions in the ADD scenario.
J. R. Mureika, Mureika, Jonas R.
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source