Results 61 to 70 of about 85,058 (265)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Non-trivial thick brane realisations with 3-forms
Journal of High Energy PhysicsWe explore the construction of four-dimensional thick branes supported by massless 3-forms in a five-dimensional bulk space. The required residual Poincaré symmetry on the brane is realised as a combination of the bulk symmetries and the internal gauge ...
Bruno J. Barros, Jose Beltrán Jiménez
doaj +1 more source
Resummed inclusive cross-section in ADD model at N3LL
Journal of High Energy Physics, 2020 We present three loop soft-plus-virtual (SV) corrections to the spin-2 production at the Large Hadron Collider (LHC). For this calculation, we make use of the recently computed quark and gluon three loop form factors for the spin-2 production, the ...
Goutam Das, M. C. Kumar, Kajal Samanta
doaj +1 more source
THE MINIMAL LENGTH AND LARGE EXTRA DIMENSIONS [PDF]
Modern Physics Letters A, 2004 Planck scale physics represents a future challenge, located between particle physics and general relativity. The Planck scale marks a threshold beyond which the old description of spacetime breaks down and conceptually new phenomena must appear. Little is known about the fundamental theory valid at Planckian energies, except that it necessarily seems ...
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Gravitational echoes from braneworlds
Journal of High Energy PhysicsGravitational echoes can be used to probe the structure of spacetime. In this paper, we investigate the gravitational echoes in different braneworld models in five-dimensional spacetime. We derive the gravitational perturbation equations of these models,
Chun-Chun Zhu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Searching for a dark dimension right-handed neutrino in KATRIN
Journal of High Energy PhysicsWe study the possibility that the Right-handed neutrino is a five-dimensional state propagating along a micron size extra dimension, as required in the dark dimension proposal.
Ignatios Antoniadis +2 more
doaj +1 more source
Constraining compressed versions of MUED and MSSM using soft tracks at the LHC
Journal of High Energy Physics, 2017 A compressed spectrum is an anticipated hideout for many beyond standard model scenarios. Such a spectrum naturally arises in the minimal universal extra dimension framework and also in supersymmetric scenarios.
Sabyasachi Chakraborty +2 more
doaj +1 more source
Light sterile neutrinos from large extra dimensions [PDF]
Physics Letters B, 2000 10 pages, no figure, remarks and references ...
Ma, Ernest +2 more
openaire +2 more sources