Results 121 to 130 of about 11,865,686 (236)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Experimental Biology and MedicinePharmacogenomics (PGx) holds the promise of personalizing medical treatments based on individual genetic profiles, thereby enhancing drug efficacy and safety.
Dan Li +11 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Political Science Research and MethodsUnderstanding how political information is transmitted requires tools that can reliably and scalably capture complex signals in text. While existing studies highlight interest groups as strategic information providers, empirical analysis has been ...
Dahyun Choi +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Finding Groups in Large Data Sets [PDF]
This paper aims to give an overview of methods to find groups in large data sets, such as household expenditure survey data. These methods are grouped in three: cluster analysis, dimension reduction and basic explorative methods. The emphasis is put on a
Adrian Müller
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Large localizations of finite groups
Journal of Algebra, 2008 We construct examples of localizations in the category of groups which take the Mathieu group $M_{11}$ to groups of arbitrarily large cardinality which are ``abelian up to finitely many generators''. The paper is part of a broader study on the group theoretic properties which are or are not preserved by localizations.
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Periodic quotients of hyperbolic and large groups
, 2009 Let G be either a non-elementary (word) hyperbolic group or a large group (both in the sense of Gromov). In this paper we describe several approaches for constructing continuous families of periodic quotients of G with various properties.The first three ...
Olshanskii, Alexander Yu. +2 more
core +1 more source