Results 131 to 140 of about 11,865,686 (236)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Algorithms for polycyclic-by-finite groups [PDF]
A set of fundamental algorithms for computing with polycyclic-by-finite groups is presented here. Polycyclic-by-finite groups arise naturally in a number of contexts; for example, as automorphism groups of large finite soluble groups, as quotients of ...
Sinanan, Shavak
core
Normal automorphisms of relatively hyperbolic groups
, 2010 An automorphism of a group G is normal if it fixes every normal subgroup of G setwise. We give an algebraic description of normal automorphisms of relatively hyperbolic groups.
D. Osin +3 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Astrophysical Journal LettersWe investigated the alignment between the angular momenta of galaxy groups and the spines of their associated cosmic filaments. Our results demonstrate a significant tendency for these two orientations to be perpendicular, indicating that the rotation of
Yu Rong, Peng Wang, Xiao-xiao Tang
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Sublinear quasiconformality and the large-scale geometry of Heintze groups [PDF]
, 2020 v1->v2: shortened, revised. Lemma 2.3 and definition of Cdim corrected. Proof of main theorem simplified. Figure 4 added.This article analyzes sublinearly quasisymmetric homeo-morphisms (generalized quasisymmetric mappings), and draws applications to the
Pallier, Gabriel
core
Groups with large centralizer subgroups.
, 2009 Let \(C_G(X)\) denote the centralizer of a subgroup \(X\) of a group \(G\). A subgroup \(X\) of \(G\) is called self-centralizing in \(G\) if \(C_G(X)\leq X\). The paper is concerned with groups in which the set of non-Abelian self-centralizing subgroups is small in some sense.
DE FALCO, MARIA +2 more
openaire +3 more sources